Aging and Heart Failure: Mechanisms and Management

ISBN-13: 9781493902675 / Angielski / Twarda / 2014 / 475 str.

Bodh I. Jugdutt

Opis

This book synthesizes the major research advances in molecular, biochemical and translational aspects of aging and heart failure over the last four decades and addresses future directions in management and drug discovery. It presents clinical issues and molecular mechanisms related to heart failure, including the changing demographics in the aging population with heart failure; hypertension and prevention of diastolic heart failure in the aging population; polypharmacy and adverse drug reactions in the aging population with heart failure; changes in the heart that accompany advancing age from humans to molecules; aging-associated alterations in myocardial inflammation and fibrosis and aging-related changes in mitochondrial function and implications for heart failure therapy. The book succinctly summarizes the large volume of data on these key topics and highlights novel pathways that need to be explored. Featuring contributions from leading clinician-scientists, Aging and Heart Failure: Mechanisms and Management is an authoritative resource on the major clinical issues in heart failure therapy in the elderly for cardiologists, gerontologists and internists.

Recenzje

From the reviews:
"This book details the clinical, physiological, and molecular aspects of heart failure pathophysiology, diagnosis, and management. ... The book caters mainly to advanced care practitioners in adult cardiovascular disease and primary care, including physicians, physician assistants, and nurse practitioners. Investigators with an interest in the molecular changes of the aging cardiovascular system also would benefit from this book. Finally, nurses who are part of a heart failure team or care for patients with cardiovascular complications will find it useful." (Shawn Ragbir, Doody's Book Reviews, June, 2014)

Spis treści

Ch. 1: Changing demographics of the aging population with heart failure and implications for therapy

            Bodh I. Jugdutt

Ch. 2: Biology of aging and implications for heart failure therapy and prevention

            Bodh I. Jugdutt

Ch. 3: Hypertension and prevention of diastolic heart failure in the aging population

            Wilbert S. Aronow

Maciej Banach

Ali Ahmed

Ch. 4: Aging and optimal therapy of systolic heart failure in the elderly

            Nakul Chander Sharma

Bodh I. Jugdutt

 

Ch. 5: Atrial fibrillation and heart failure in the aging population

            Pedram Kazemian

Bodh I. Jugdutt

Ch. 6: Optimizing therapy of heart failure in the aging population with monitoring in clinics

            John R. Dimitry

Justin A. Ezekowitz

Ch. 7:  Cardiac alterations in aging, hypertension and diastolic heart failure

            Edith Pituskin

D. Ian Paterson

Ch. 8: Polypharmacy and adverse drug reactions in the aging population with heart failure

            Michael W. Rich

William J. Nienaber

Ch. 9: Aging-related changes in vascular biology and implications for heart failure therapy in the aging population

            Michael Sean McMurtry

Ch. 10: Biomarkers and optimal management of heart failure in the aging population

            Hanna K. Gaggin

James L. Januzzi, Jr.

Ch. 11: Benefits of Exercise in the elderly

            Ezra A. Amsterdam

C. Tissa Kappagoda

Ch. 12: The RAAS in heart failure: an update on clinical trials and opportunities for therapy

            C. Tissa Kappagoda

Ezra A. Amsterdam

Ch. 13: Aging and diastolic dysfunction – the interplay of inflammation and extracellular matrix regulation        

            Peter Moritz Becher

Dirk Westermann,

Carsten Tschöpe

Ch. 14: Reperfusion and vasodilator therapy in elderly patients with STEMI and heart failure. Improving outcomes

Bodh I. Jugdutt,

Anwar Jelani

Seraj Abualnaja

Nakul Chander Sharma

Joseph Szeman Wong

Ch. 15: Erythropoietin therapy for heart failure

            Margarita Borovka

Mathew S. Maurer

Ch. 16: Role of resistin in heart failure in the elderly

            Yasuchika Takeishi

Ch. 17: Role of coronary artery calcium in cardiovascular risk stratification and management in the aging population

            Craig R. Butler

Paolo Raggi

Ch. 18: Aging-and remodeling of the RAS and RAAS and related pathways. Implications for heart failure therapy

Bodh I. Jugdutt

Ch. 19: Aging and right ventricular failure from pulmonary hypertension: Effect of right ventricular and pulmonary artery remodeling

Joseph Szeman Wong

Bodh I. Jugdutt

Ch. 20: Biomarkers of cardiovascular aging

           Nirankar S. Neki

Paramjit S. Tappia

Naranjan S. Dhalla

Ch. 21: Changes in the heart that accompany advancing age: Humans to molecules

            Edward G. Lakatta

Harold A. Spurgeon

Andzej M. Janczewski

Ch. 22: Aging-related changes in cell death and cell survival pathways and implications for heart failure therapy

            Guido R.Y. De Meyer

Dorien M. Schrijvers

Wim Martinet

Ch. 23: Aging-related changes in telomeres and telomerases and implications for heart failure therapy

            Pim van der Harst

Dirk J. van Veldhuisen

Ch. 24: Aging associated alterations in myocardial inflammation and fibrosis: pathophysiological perspectives and clinical implications

            Arti V. Shinde

Nikolaos G Frangogiannis

Ch. 25: Aging-related changes in extracellular matrix: implications for ventricular remodeling following myocardial infarction 

            Nguyen T. Nguyen

Andriy Yabluchanskiy

Lisandra E. de Castro Brás

Yu-Fang Jin

Merry L. Lindsey

Ch. 26: Calcium handling defects and changes in cardiac function in the aging heart

            Adriana Adameova

Nirankar S. Neki

Paramjit S. Tappia

Naranjan S. Dhalla

Ch. 27: Integrins: Implications for aging in heart failure therapy

            Laura L. Daniel

William L. Joyner

Mahipal Singh

Krishna Singh

Ch. 28: Adipokines as novel biomarkers in aging and heart failure

            Ken Shinmura

Ch. 29: Aging-related changes in cellular and molecular mechanisms of post-infarction remodeling. Implications for heart failure therapy

            Henry Han-Jen Shih

Andrew J. Boyle

Ch. 30: Aging-related changes in mitochondrial function and implication for heart failure therapy

            Satoaki Matoba

Atsushi Hoshino

Hiroaki Matsubara

Ch. 31: Regulation of SERCA via oxidative modifications: Implications for the pathophysiology of diastolic dysfunction in the aging heart

            Fuzhong Qin

Richard A. Cohen

Wilson S. Colucci

Ch. 32: SMP-30 and aging-related cardiac remodeling and heart failure

            Satoshi Suzuki

Yasuchika Takeishi