Ageing: Lessons from C. Elegans

ISBN-13: 9783319447018 / Angielski / Twarda / 2016 / 439 str.

Anders Olsen; Matthew Gill

Opis

This book brings together in one volume the current state of ageing research in the nematode Caenorhabditis elegans. The authors are leading researchers in the field, placing this topic in the context of human ageing, describing how and why basic discoveries in this simple organism have impacted our prospects for intervention in the ageing process. The authors cover a broad range of topics with regards to organismal and reproductive ageing including anatomical, physiological and biochemical changes, as well as genetic and environmental interventions that promote longevity and ameliorate age-related disease. Ageing is the single most important factor determining the onset of human disease in developed countries. With current worldwide demographic trends indicating that the number of individuals over the age of 65 will continue to rise, it is clear that an understanding of the processes that underpin ageing and age-related disease represents a key challenge in the biomedical sciences. In recent years there have been huge advances in our understanding of the ageing process and many of these have stemmed from genetic analysis of C. elegans. With no analogous book in this subject area this work will be of interest to a wide audience, ranging from academic researchers to the general public.

Spis treści

Chapter 1
Introduction - Anders Olsen and Matthew S. Gill

Chapter 2
Effects of aging on the basic biology and anatomy of C. elegans - Laura A. Herndon, Catherine A. Wolkow, Monica Driscoll and David H. Hall

Chapter 3
Dauer Formation and Ageing -  Pedro Reis Rodrigues, Kailiang Jia and Matthew S. Gill

Chapter 4
Longevity regulation by insulin/IGF-1 signaling  -  Seon Woo A. An, Murat Artan, Sangsoon Park, Ozlem Altintas, and Seung-Jae V. Lee

Chapter 5
Mitochondrial longevity pathways - Alfonso Schiavi and Natascia Ventura

Chapter 6
Influences of Germline Cells on Organismal Lifespan and Healthspan - Francis R.G. Amrit and Arjumand Ghazi

Chapter 7
Reproductive Aging -  Cheng Shi & Coleen T. Murphy

Chapter 8
Nervous System Ageing -  Claire Bénard and Maria Doitsidou 

Chapter 9
Stress Response Pathways - Dana L. Miller*, Joseph Horsman, and Frazer Heinis

Chapter 10
Oxidative Stress - Bart P. Braeckman, Patricia Back, Filip Matthijssens

Chapter 11
Genome stability and ageing  - Aditi U. Gurkar, Matthew S. Gill and Laura J. Niedernhofer

Chapter 12
Protein homeostasis and ageing in C. elegans -  Silvestre Alavez

Chapter 13
Translational control of longevity - Jarod Rollins and Aric Rogers

Chapter 14
Lipid Metabolism, Lipid Signaling and Longevity -  Jonathon Duffy, Ayse Sena Mutlu, Meng C. Wang

Chapter 15
Autophagy and ageing -  Malene Hansen

Chapter 16
Dietary restriction in C. elegans - Yue Zhang and William B. Mair

Chapter 17
Integration of metabolic signals - Dana A. Lynn and Sean P. Curran 

Chapter 18
Microbiota, Probiotic Bacteria and Ageing -  Katrine V. Christensen, Maria G. Morch, Tine H. Morthorst, Simon Lykkemark and Anders Olsen

Chapter 19
The Future of Worm Ageing - Gordon J. Lithgow

Index