Advances in Immunology in China - Part B: Volume 145

ISBN-13: 9780128178782 / Angielski / Twarda / 2020 / 198 str.

Chen Dong; Zhengfan Jiang

Spis treści

1. Deciphering the pathways to antiviral innate immunity and inflammation Qing Yang and Hong-Bing Shu 2. Tissue-resident NK cells and other innate lymphoid cells Jing Zhou, Zhigang Tian and Hui Peng 3. The strategies of targeting the NLRP3 inflammasome to treat inflammatory diseases Hua Jiang, Tao Gong and Rongbin Zhou 4. Fine-tuning of antiviral innate immunity by ubiquitination Yi Zheng and Chengjiang Gao 5. Metabolic regulation of innate immunity Shaonan Liang, Liangliang Ji, Lan Kang and Xiaoyu Hu 6. Regulation of MHC class I-independent NK cell education by SLAM family receptors Shasha Chen, Dan Li, Yuande Wang, Qiaozhen Li and Zhongjun Dong 7. Metalloimmunology: The metal ion-controlled immunity Chenguang Wang, Rui Zhang, Xiaoming Wei, Mengze Lv and Zhengfan Jiang

O autorze

Chen Dong is at Tsinghua University, Beijing, China Zhengfan Jiang is a Peking-Tsinghua Center for Life Sciences (CLS) Investigator, a tenured full professor and Vice Dean of the School of Life Sciences (SLS) at Peking University (PKU). He works on innate immunity and related cell signaling and, more specifically, on the molecular mechanisms of host defense against virus infection. His lab has identified ERIS which is also named STING and MITA and provided molecular insights into the coordination among viral infection-induced cytokine production, inflammation and apoptosis. Recently, his lab has identified Mn2+ as a critical component required for antiviral innate immunity by activating the cGAS-STING pathway. He has been honored to the National Science Foundation for Distinguished Young Scholars, China and the Cheung Kong Scholar and tenured full professor at PKU.