Advances in Immunology: Volume 98

ISBN-13: 9780123743312 / Angielski / Twarda / 2008 / 230 str.

Frederick W. Alt

Opis

Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities.

* Contributions from leading authorities and industry experts
* Informs and updates on all the latest developments in the field
* Reference and guide for scientists and specialists involved in advancements in immunology

Recenzje

"Provides an extremely valuable source of reference and many stimulating ideas...the main repository of information in a rapidly developing subject." --The Lancet

Spis treści

1. Immune regulation by B cells and antibodies: a view towards the clinic
Kai Hoehlig, Vasiliki Lampropoulou, Toralf Roch, Patricia Neves, Elisabeth Calderon-Gomez, Stephen M. Anderton, Ulrich Steinhoff, Simon Fillatreau
2. Cumulative Environmental Changes, Antigen Exposure, and the Increase of Allergy
Tse Wen Chang and Ariel Y. Pan
3. FceR1 signalling *tentative title*
J. Rivera
4. TCR triggering mechanism *tentative title*
Kai W. Wucherpfennig
5. IL-17 *tentative title*
Casey Weaver

O autorze

Frederick W. Alt is a Howard Hughes Medical Institute (HHMI) Investigator and Director of the Program in Cellular and Molecular Medicine (PCMM) at Boston Children's Hospital (BCH). He is the Charles A. Janeway Professor of Pediatrics and Professor of Genetics at Harvard Medical School. He works on elucidating mechanisms that generate antigen receptor diversity and, more generally, on mechanisms that generate and suppress genomic instability in mammalian cells, with a focus on the immune and nervous systems. Recently, his group has developed senstive genome-wide approaches to identify mechanisms of DNA breaks and rearrangements in normal and cancer cells. He has been elected to the U.S. National Academy of Sciences, the U.S. National Academy of Medicine, and the European Molecular Biology Organization. His awards include the Albert Szent-Gyorgyi Prize for Progress in Cancer Research, the Novartis Prize for Basic Immunology, the Lewis S. Rosensteil Prize for Distinugished work in Biomedical Sciences, the Paul Berg and Arthur Kornberg Lifetime Achievement Award in Biomedical Sciences, and the William Silan Lifetime Achievement Award in Mentoring from Harvard Medical School.