Advances in Immunology: Volume 147

ISBN-13: 9780128207567 / Angielski / Twarda / 2020 / 146 str.

Frederick W. Alt

Spis treści

1. Histone deacetylases as targets in autoimmune and autoinflammatory diseases Wilfried Ellmeier 2. The advancing area of the mechanisms involved in the evolution of HIV-1 neutralizing antibodies Mattia Bonsignori 3. T cells in latent viral infections Dietmar Zehn 4. Communications of dendritic cells with T cells and NK cells in cancerous tissues Jan Böttcher 5. Mechanism and Regulation of Class Switch Recombination by IgH transcriptional Control Elements Amine Khamlichi 6. IL-2 partial agonist Warren Leonard 7. Preserving Immune Homeostasis with A20 Averil Ma 8. The design of vaccine strategies to elicit HIV-1 broadly neutralizing antibodies Joseph Jardine

O autorze

Frederick W. Alt is a Howard Hughes Medical Institute (HHMI) Investigator and Director of the Program in Cellular and Molecular Medicine (PCMM) at Boston Children's Hospital (BCH). He is the Charles A. Janeway Professor of Pediatrics and Professor of Genetics at Harvard Medical School. He works on elucidating mechanisms that generate antigen receptor diversity and, more generally, on mechanisms that generate and suppress genomic instability in mammalian cells, with a focus on the immune and nervous systems. Recently, his group has developed senstive genome-wide approaches to identify mechanisms of DNA breaks and rearrangements in normal and cancer cells. He has been elected to the U.S. National Academy of Sciences, the U.S. National Academy of Medicine, and the European Molecular Biology Organization. His awards include the Albert Szent-Gyorgyi Prize for Progress in Cancer Research, the Novartis Prize for Basic Immunology, the Lewis S. Rosensteil Prize for Distinugished work in Biomedical Sciences, the Paul Berg and Arthur Kornberg Lifetime Achievement Award in Biomedical Sciences, and the William Silan Lifetime Achievement Award in Mentoring from Harvard Medical School.