Advances in Immunology: Volume 134

ISBN-13: 9780128124079 / Angielski / Twarda / 2017 / 360 str.

Frederick Alt

Opis

Advances in Immunology, Volume 134, the latest release in a long-established and highly respected publication, presents current developments and comprehensive reviews in immunology. Topics covered in this new volume include γδ T Cells and B Cells, A Chemoattractant-Guided Walk Through Lymphopoiesis: From Hematopoietic Stem Cells to Mature B Lymphocytes. Tissue Specific Regulation of Dendritic Cell Development and Function, and the Regulation of Innate and Adaptive Immunity by Transforming Growth Factor Beta (TGFβ). Articles in this long running series address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.

• Contains contributions from leading authorities
• Informs and updates on all the latest developments in the field of immunology

Spis treści

1. ?d T Cells and B Cells W.K. Born, Y. Huang, R.L Reinhardt, H. Huang, D. Sun and R.L. O'Brien 2. A Chemoattractant-Guided Walk Through Lymphopoiesis: From Hematopoietic Stem Cells to Mature B Lymphocytes V.Y. Lim, S. Zehentmeier, C. Fistonich and J.P. Pereira 3. Tissue Specific Regulation of Dendritic Cell Development and Function D. Pakalniskyte and B.U. Schraml 4. Regulation of Innate and Adaptive Immunity by Transforming Growth Factor Beta (TGFß) A. Kelly, S.A. Houston, E. Sherwood, J. Casulli and M.A. Travis 5. Humanized Immunoglobulin Mice: Models for HIV Vaccine Testing and  Studying the Broadly Neutralizing Antibody Problem L. Verkoczy

O autorze

Frederick W. Alt is a Howard Hughes Medical Institute (HHMI) Investigator and Director of the Program in Cellular and Molecular Medicine (PCMM) at Boston Children's Hospital (BCH). He is the Charles A. Janeway Professor of Pediatrics and Professor of Genetics at Harvard Medical School. He works on elucidating mechanisms that generate antigen receptor diversity and, more generally, on mechanisms that generate and suppress genomic instability in mammalian cells, with a focus on the immune and nervous systems. Recently, his group has developed senstive genome-wide approaches to identify mechanisms of DNA breaks and rearrangements in normal and cancer cells. He has been elected to the U.S. National Academy of Sciences, the U.S. National Academy of Medicine, and the European Molecular Biology Organization. His awards include the Albert Szent-Gyorgyi Prize for Progress in Cancer Research, the Novartis Prize for Basic Immunology, the Lewis S. Rosensteil Prize for Distinugished work in Biomedical Sciences, the Paul Berg and Arthur Kornberg Lifetime Achievement Award in Biomedical Sciences, and the William Silan Lifetime Achievement Award in Mentoring from Harvard Medical School.