Advances in Immunology: Volume 133

ISBN-13: 9780128124093 / Angielski / Twarda / 2017 / 242 str.

Frederick Alt

Opis

Advances in Immunology, Volume 133, the latest release in this long-established and highly respected publication, presents current developments and comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.

• Contains contributions from leading authorities
• Informs and updates on all the latest developments in the field of immunology
• Addresses molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities

Spis treści

1. Macrophages and Mitochondria: A Critical Interplay Between Metabolism, Signaling, and the Functional Activity 2. Molecular Mechanisms of Somatic Hypermutation and Class Switch Recombination 3. Emerging Major Histocompatibility Complex Class I-Related Functions of NLRC5 4. Nucleic Acid Immunity 5. About Training and Memory: NK-Cell Adaptation to Viral Infections

O autorze

Frederick W. Alt is a Howard Hughes Medical Institute (HHMI) Investigator and Director of the Program in Cellular and Molecular Medicine (PCMM) at Boston Children's Hospital (BCH). He is the Charles A. Janeway Professor of Pediatrics and Professor of Genetics at Harvard Medical School. He works on elucidating mechanisms that generate antigen receptor diversity and, more generally, on mechanisms that generate and suppress genomic instability in mammalian cells, with a focus on the immune and nervous systems. Recently, his group has developed senstive genome-wide approaches to identify mechanisms of DNA breaks and rearrangements in normal and cancer cells. He has been elected to the U.S. National Academy of Sciences, the U.S. National Academy of Medicine, and the European Molecular Biology Organization. His awards include the Albert Szent-Gyorgyi Prize for Progress in Cancer Research, the Novartis Prize for Basic Immunology, the Lewis S. Rosensteil Prize for Distinugished work in Biomedical Sciences, the Paul Berg and Arthur Kornberg Lifetime Achievement Award in Biomedical Sciences, and the William Silan Lifetime Achievement Award in Mentoring from Harvard Medical School.