Advances in Immunology: Volume 124

ISBN-13: 9780128001479 / Angielski / Twarda / 2014 / 308 str.

Frederick W. Alt

Opis

Advances in Immunology, a long-established and highly respected publication, presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for the future.

• Contributions from leading authorities
• Informs and updates on all the latest developments in the field

Recenzje

"The series which all immunologists need." --The Pharmaceutical Journal

"Advances in Immunology must find itself among the most active volumes in the libraries of our universities and institutions." --Science

"Deserves a permanent place in biomedical libraries as an aid in research and in teaching." --Journal of Immunological Methods

Spis treści

1. Group 2 Innate Lymphoid Cells in the Lung
   Li Yin Drake and Hirohito Kita
2. The Ubiquitin System in Immune Regulation
   Yoon Park, Hyung-seung Jin, Daisuke Aki, Jeeho Lee and Yun-Cai Liu
3. How Immunoglobulin G Antibodies Kill Target Cells: Revisiting an Old Paradigm
   Markus Biburger, Anja Lux and Falk Nimmerjahn
4. A Transendocytosis Perspective on the CD28/CTLA-4 Pathway
   Blagoje Soskic, Omar S. Qureshi, Tiezheng Hou and David M. Sansom
5. How to Trigger a Killer - Modulation of Natural Killer Cell Reactivity on Many Levels
   Carsten Watzl
6. Roles for Helper T Cell Lineage-Specifying Transcription Factors in Cellular Specialization
   Amy S. Weinmann
7. MHC Class I Recognition by Monocyte/Macrophage-Specific Receptors
   Ryotaro Yoshida
8. Regulation of Regulatory T Cells: Epigenetics and Plasticity
   Masahiro Okada, Sana Hibino, Kazue Someya  and Akihiko Yoshmura
   

O autorze

Frederick W. Alt is a Howard Hughes Medical Institute (HHMI) Investigator and Director of the Program in Cellular and Molecular Medicine (PCMM) at Boston Children's Hospital (BCH). He is the Charles A. Janeway Professor of Pediatrics and Professor of Genetics at Harvard Medical School. He works on elucidating mechanisms that generate antigen receptor diversity and, more generally, on mechanisms that generate and suppress genomic instability in mammalian cells, with a focus on the immune and nervous systems. Recently, his group has developed senstive genome-wide approaches to identify mechanisms of DNA breaks and rearrangements in normal and cancer cells. He has been elected to the U.S. National Academy of Sciences, the U.S. National Academy of Medicine, and the European Molecular Biology Organization. His awards include the Albert Szent-Gyorgyi Prize for Progress in Cancer Research, the Novartis Prize for Basic Immunology, the Lewis S. Rosensteil Prize for Distinugished work in Biomedical Sciences, the Paul Berg and Arthur Kornberg Lifetime Achievement Award in Biomedical Sciences, and the William Silan Lifetime Achievement Award in Mentoring from Harvard Medical School.