Advances in Immunology: Volume 82

ISBN-13: 9780120224821 / Angielski / Twarda / 2004 / 380 str.

Frederick Alt

Opis

Advances in Immunology presents current developments as well as comprehensive reviews in immunology. Articles address the wide range of topics that comprise immunology, including molecular and cellular activation mechanisms, phylogeny and molecular evolution, and clinical modalities. Edited and authored by the foremost scientists in the field, each volume provides up-to-date information and directions for future research.

Spis treści

Transcriptional regulation in neutrophils: Teaching old cells new tricks
Tumor vaccines
Immunotherapy of allergic disease
Interactions of immunoglobulins outside the antigen-combining site
The role of antibodies in mouse models of rheumatoid arthirits, and relevance to human disease
MUC1 Immunobiology: from discovery to clinical applications
Human models of inherited immunoglobulin class switch recombination and somatic hypermutation defects (Hyper-IgM syndromes)
The Biologic Role of C1 Inhibitor in Regulation of Vascular Permeability and Modulation of Inflammation

O autorze

Frederick W. Alt is a Howard Hughes Medical Institute (HHMI) Investigator and Director of the Program in Cellular and Molecular Medicine (PCMM) at Boston Children's Hospital (BCH). He is the Charles A. Janeway Professor of Pediatrics and Professor of Genetics at Harvard Medical School. He works on elucidating mechanisms that generate antigen receptor diversity and, more generally, on mechanisms that generate and suppress genomic instability in mammalian cells, with a focus on the immune and nervous systems. Recently, his group has developed senstive genome-wide approaches to identify mechanisms of DNA breaks and rearrangements in normal and cancer cells. He has been elected to the U.S. National Academy of Sciences, the U.S. National Academy of Medicine, and the European Molecular Biology Organization. His awards include the Albert Szent-Gyorgyi Prize for Progress in Cancer Research, the Novartis Prize for Basic Immunology, the Lewis S. Rosensteil Prize for Distinugished work in Biomedical Sciences, the Paul Berg and Arthur Kornberg Lifetime Achievement Award in Biomedical Sciences, and the William Silan Lifetime Achievement Award in Mentoring from Harvard Medical School.