Advances in Chromatography, Volume 49

ISBN-13: 9781439840917 / Angielski / Twarda / 2011 / 461 str.

Eli Grushka; Nelu Grinberg

Opis

For more than four decades, scientists and researchers have relied on this series for the most up-to-date information on chromatographic methods and applications. This volume again compiles the work of expert contributors in order to present timely and cutting-edge reviews on a variety of related topics. Each author's clear presentation of topics and vivid illustrations make the material accessible to those at all levels of experience. This edition covers method harmonization, strategies for rapid HPLC development, multidimensional ion chromatography, quantitative in silico analysis, mechanistic aspects of chiral discrimination on protein phases, novel materials for chromatographic analysis, and advances in CE-MS based glycoanalysis.

Spis treści

Retention Mechanism for Ion-Pair Chromatography with Chaotropic Reagents: From Ion-Pair Chromatography toward a Unified Salt Chromatography. Mechanistic Aspects of Chiral Recognition on Protein-Based Stationary Phases. Mechanistic Aspects and Applications of Chiral Ligand-Exchange Chromatography. Glycosylation Analysis of Proteins, Proteoglycans, and Glycolipids Using Capillary Electrophoresis and Mass Spectrometry. Oligonucleotide Adducts as Biomarkers for DNA Damages: Analysis by Mass Spectrometry Coupled to Separation Methods. Quantitative In Silico Analysis of the Specificity of Graphitized (Graphitic) Carbons. Application of Column-Switching Methods in HPLC for Evaluating Pharmacokinetic Parameters. Chromatographic Procedures in a Regulated Environment. The Use of Novel Materials as Solid-Phase Extractors for Chromatographic Analysis. Thin-Layer and High-Performance Thin Layer Chromatographic Analysis of Biological Samples. Index.

O autorze

Eli Grushka is currently with Hebrew University of Israel, Jerusalem. Nelu Grinberg is with Boehringer-Ingelheim Pharmaceuticals of Ridgefield, Connecticut.