Advanced Organic Synthesis: A Laboratory Manual

ISBN-13: 9781482244960 / Angielski / Miękka / 2015 / 107 str.

Dmitry V. Liskin; Penny Chaloner

Opis

Laboratory experience equips students with techniques that are necessary for professional practice. Advanced Organic Synthesis: A Laboratory Manual focuses on a mechanistic background of key reactions in organic chemistry, gives insight into well-established trends, and introduces new developments in the field. The book features experiments performed by primary author Dmitry Liskin while he was a graduate student, providing a real-life quality to the experiments by using examples that have actually been conducted. It also includes recent experiments that have been published in peer-reviewed journals. The experiments are presented in a brief and simple manner, including bulleted lists of the required materials and equipment as well as step-by-step walkthroughs. Each experiment also carefully details safety issues and waste disposal methods. Emphasizing techniques and approaches used in more advanced labs, Advanced Organic Synthesis: A Laboratory Manual gives undergraduates the theoretical knowledge and practical experience they need to succeed at more advanced levels of research involving organic synthesis at the graduate or industrial level.

Spis treści

Diastereoselective Reduction of Estrone. Synthesis of 2,2-Dimethyl-4-pentene-1-amine. Protection of 2,2-Dimethyl-4-pentene-1-amine. Optimization of the Reaction Conditions for the Aminofluorination of N-(2,2-Dimethylpent-4-enyl)-2-toluenesulfonamide. Asymmetric Robinson Annulation. Formation of N- Benzylcinchonidinium Chloride from Cinchonidine. Chiral Resolution of BINOL (1,1’-bi-2-Naphthol) with N- Benzylcinchonidinium Chloride. Transesterification of Phosphatidylcholine and FAME Quantification. Green Chemistry: Solventless Sequential Aldol and Michael Reactions in the Synthesis of Kröhnke Pyridine. Carbonyl Chemistry in a Multistep Synthesis. Multistep Synthesis of a Bioactive Peptidomimetic. Total Synthesis of a Natural Product: Caffeic Acid Phenethyl Ester (CAPE). Appendix: Essential Laboratory Techniques.