Adult Acute Lymphocytic Leukemia: Biology and Treatment

ISBN-13: 9781607617068 / Angielski / Twarda / 2010 / 388 str.

Anjali Advani; Hillard Lazarus

Opis

The current explosion of new areas of controversy in the treatment of acute lymphocytic leukemia in adults and young adults makes this comprehensive book a much needed reference for hematologists and oncologists. Topics of discussion include indications for allogeneic bone marrow transplant in first complete remission, the treatment of your adults with ALL, the role of minimal residual disease in making treatment decisions, and the treatment of Philadelphia chromosome positive ALL with the advent of the tyrosine kinase inhibitors. The full spectrum of ALL subtypes and their treatments are covered. Focusing especially upon the adult ALL patient, this book is the first of its kind. It provides a complete overview of diagnosis, molecular pathogenesis, and treatment for this important patient population.

Recenzje

From the reviews:

"The focus of this book is on acute lymphocytic leukemia in adults, with frequent allusions to the childhood form of disease. ... the only recent text solely focused on acute lymphocytic leukemia as it relates to subtypes of disease in each of the adult age groups. It is up to date and well referenced, and it integrates basic, translational, and clinical science. As such it serves as a unique resource for scientists and clinicians in the field of acute lymphocytic leukemia." (Paulette Mehta, Journal of the American Medical Association, June, 2011)

"Twenty-three chapters cover a range of clinically biased topics, from diagnosis and epidemiology to assessment of response to therapy, salvage protocols and the late effects of successful therapy. The text is broken up by tables, graphs and occasional colour illustrations, while extensive lists of references supplement each chapter. ... A section on the biology of ALL helps to explain the diversity and underlying genetic instability of the disease. ... this collection of reviews will prove to be a very useful supplementary reference text." (Maria H. Gilleece, Bulletin of the Royal College of Pathologists, April, 2012)

Spis treści

Chapter 1 A Perspective on the Treatment of Acute Lymphoblastic Leukemia Charles A Schiffer Chapter 2 Clinical Features and Making the Diagnosis Olga Frankfurt LoAnn Peterson Martin S. Tallman Chapter 3 The Biology of Adult Acute Lymphoblastic Leukemia Jerald Radich Olga Sala Chapter 4 Minimal Residual Disease in Acute Lymphoblastic Leukemia Patrick A. Zweidler-McKay Michael J. Borowitz Chapter 5 Cytogenetics Anthony V. Moorman Christine J. Harrison Chapter 6 Acute Lymphoblastic leukemia: Epidemiology Matthew Hourigan Anthony H. Goldstone Chapter 7 Prognostic Factors in Acute Lymphoblastic Leukemia Adele K. Fielding Chapter 8 The Generalized Care of the Patient with Acute Lymphoblastic Leukemia Anthony R. Mato Alicia K. Morgans Selina M. Luger Chapter 9 Treatment of Acute Lymphoblastic Leukemia in Middle-Age and Older Adults Vaishalee Kenkre Richard A. Larson Chapter 10 Pharmacology of Acute Lymphoblastic Leukemia Therapy Paul M. Barr Richard J. Creger Nathan A. Berger Chapter 11 Assessment of Response to Treatment Christopher A. Fox A.K. McMillan Chapter 12 T-cell Acute Lymphoblastic Leukemia Andrei R. Shustov Frederick R. Appelbaum Chapter 13 Burkitt Leukemia and Lymphoma Kevin A. David Mark Roberts LoAnn Peterson Andrew M. Evens Chapter 14 Treatment of Acute Lymphoblastic Leukemia in Young Adults Nicolas Boissel Francoise Huguet Herve Dombret Chapter 15 Treatment of Philadephia Chromosome Positive Acute Lymphoblastic Leukemia Deborah Thomas Chapter 16 Molecular Therapies Camille Abboud Chapter 17 Treatment of Relapsed/ Refractory Acute Lymphoblastic Leukemia Dan DeAngelo Chapter 18 Allogenic Stem Cell Transplantation for Acute Lymphoblastic Leukemia in Adults David I. Marks Chapter 19 Hematopoietic Stem Cell Transplantation in Philadelphia-positive Acute Lymphoblastic Leukemia Christy J. Stotler Edward Copelan Chapter 20 Special Challenges: Genetic polymorphisms and therapy Maja Krainovic Chapter 21 Late Consequences of Therapy of Acute Lymphoblastic Leukemia Mark R. Litzow Chapter 22 Immunotherapy for Acute Lymphocytic Leukemia Jacalyn Rosenblatt David Avigan Chapter 23 Unique Subtypes in Acute Lymphoblastic Leukemia Elisabeth Paietta

Blurb

The current explosion of new areas of controversy in the treatment of acute lymphocytic leukemia in adults and young adults makes this comprehensive book a much needed reference for hematologists and oncologists. This book assembles leading authorities from around the globe to cover the full spectrum of ALL subtypes and their treatments. Specific topics of discussion include indications for allogeneic bone marrow transplant in first complete remission, the role of minimal residual disease in making treatment decisions, the treatment of young adults, and the treatment of Philadelphia chromosome positive ALL with the advent of the tyrosine kinase inhibitors. This is the first book to focus exclusively on the adult ALL patient. It provides a complete overview of diagnosis, molecular pathogenesis, evaluation, and treatment for this important patient population.