Adherens Junctions: from Molecular Mechanisms to Tissue Development and Disease

ISBN-13: 9789400796164 / Angielski / Miękka / 2014 / 434 str.

Tony Harris

Opis

Cell-cell adhesion is fundamental for the development and homeostasis of animal tissues and organs. Adherens junctions (AJs) are the best understood cell-cell adhesion complexes. In this volume, a group of internationally recognized experts reviews AJ biology over a wide range of organization; from atoms to molecules, to protein complexes, molecular networks, cells, tissues, and overall animal development. AJs have also been an integral part of animal evolution, and play central roles in cancer development, pathogen infection and other diseases. This book addresses major questions encompassing AJ biology.
How did AJs evolve?
How do cadherins and catenins interact to assemble AJs and mediate adhesion?
How do AJs interface with other cellular machinery to couple adhesion with the whole cell?
How do AJs affect cell behaviour and multicellular development?
How can abnormal AJ activity lead to disease?

Spis treści

1. An introduction to adherens junctions: from molecular mechanisms to tissue development and disease; Tony Harris

Part I: How AJs evolved
2. Evolution of the cadherin-catenin complex; Hiroki Oda

Part II: How cadherins and catenins interact to assemble AJs
3. The three-dimensional structure of the cadherin-catenin complex; Noboru Ishiyama and Mitsuhiko Ikura
4. Biophysics of cadherin adhesion; Deborah Leckband and Sanjeevi Sivasankar
5. Adherens junction assembly; Sergey Troyanovski

Part III: How AJs interface with other cellular machinery
6. The cytoskeleton and classical cadherin adhesions; Siew Ping Han and Alpha Yap
7. Immunoglobulin superfamily receptors and adherens junctions; Yohei Shimono, Yoshiyuki Rikitake, Kenji Mandai, Masahiro Mori and Yoshimi Takai
8. Signaling from the adherens junction; Abbye McEwen, David Escobar and Cara Gottardi
9. Adherens junction turnover: regulating adhesion through cadherin endocytosis, degradation, and recycling; Benjamin Nanes and Andrew Kowalczyk

Part IV: How AJs affect cell behaviour and multicellular development
10. Adherens junctions during cell migration; Sandrine Etienne-Manneville
11. Adherens junctions and cadherins in Drosophila development; Annalisa Letizia and Marta Llimargas
12. Adherens junctions in C. elegans embryonic morphogenesis; Stephen Armenti and Jeremy Nance
13. Cadherin function during Xenopus gastrulation; Rudolf Winklbauer
14. Adherens junctions in mammalian development, homeostasis and disease: lessons from mice; Barbara Boggetti and Carien Niessen

Part V: How AJs affect tissue homeostasis and disease
15. Adherens junctions and stem cells; Terry Lechler
16. Adherens junctions and cancer; Valeri Vasioukhin
17. Adherens junctions and pathogens entry; Georgios Nikitas and Pascale Cossart

Index

Blurb

Cell–cell adhesion is fundamental for the development and homeostasis of animal tissues and organs.  Adherens junctions (AJs) are the best understood cell-cell adhesion complexes. 

In this volume, internationally recognized experts review AJ biology over a wide range of organization; from atoms to molecules, to protein complexes, molecular networks, cells, tissues, and overall animal development.  AJs have also been an integral part of animal evolution, and play central roles in cancer development, pathogen infection and other diseases.  This book addresses major questions encompassing AJ biology.

- How did AJs evolve?
- How do cadherins and catenins interact to assemble AJs and mediate adhesion?
- How do AJs interface with other cellular machinery to couple adhesion with the whole cell?
- How do AJs affect cell behaviour and multicellular development?
- How can abnormal AJ activity lead to disease?

Valuable for both newcomers and experts in the field, this book offers a comprehensive resource for the research laboratory and a teaching tool for advanced undergraduate and graduate courses in cell and developmental biology.