Adenoviruses: Model and Vectors in Virus-Host Interactions: Immune System, Oncogenesis, Gene Therapy

ISBN-13: 9783642057151 / Angielski / Miękka / 2010 / 368 str.

Walter Doerfler; Petra Bohm

Opis

After three volumes on adenoviruses in 1995 the past years have seen rapid progress in the field of adenovirus research. Moreover, adenoviruses have attracted considerable interest as vectors in gene transfer regimens. After the first volume on virion and structure, viral replication and host-cell interaction this second volume deals with the immune system, oncogenesis and gene therapy.

Spis treści

Immune System.- Evasion of the Immune System by Adenoviruses.- Immune Evasion by Adenovirus E3 Proteins: Exploitation of Intracellular Trafficking Pathways.- Adenovirus: Model and Vectors in Virus-Host Interactions.- Molecular Determinants of Adenovirus Tropisms.- Oncogenesis.- Modulation of Oncogenic Transformation by the Human Adenovirus E1A C-Terminal Region.- Cell Transformation by Human Adenoviruses.- Tumorigenesis by Adenovirus Type 12 in Newborn Syrian Hamsters.- E1A-Based Determinants of Oncogenicity in Human Adenovirus Groups A and C.- Gene Therapy.- Replicating Adenoviruses in Cancer Therapy.- Adenovirus Vectors: Biology, Design, and Production.- The Coxsackie-Adenovirus Receptor – a New Receptor in the Immunoglobulin Family Involved in Cell Adhesion.- Subject Index