Classification and Epidemiologic Aspects of Acute-on-Chronic Liver Failure Mechanisms of Disease and Multisystemic Involvement Pathology of Acute and Acute-on-Chronic Liver Failure Liver Regeneration in Acute-on-Chronic Liver Failure Viral Hepatitis and Acute-on-Chronic Liver Failure Drug-Induced Acute-on-Chronic Liver Failure: Challenges and Future Directions Nonviral or Drug-Induced Etiologies of Acute-on-Chronic Liver Failure (Autoimmune, Vascular, and Malignant) Acute-on-Chronic Liver Failure in Patients with Alcohol-Associated Hepatitis: A Review The Clinical Spectrum and Manifestations of Acute-on-Chronic Liver Failure Prognostic Models in Acute-on-Chronic Liver Failure Hepatic Encephalopathy in Acute-on-Chronic Liver Failure Bacterial Infections in Acute-on-Chronic Liver Failure Management of Portal Hypertension in Patients with Acute-on-Chronic Liver Disease Liver Transplantation in Acute-on-Chronic Liver Failure Maximizing the Donor Potential for Patients with Acute-on-Chronic Liver Failure Listed for Liver Transplant Future Approaches and Therapeutic Modalities for Acute-on-Chronic Liver Failure