Acute and Chronic Neural Stimulation Via Mechano-Sensitive Ion Channels

ISBN-13: 9783319887081 / Angielski / Miękka / 2018 / 119 str.

Andy Kah Ping Tay

Spis treści

1. Micro- and Nano-Technologies to Probe Brain Mechanobiology

2. Acute Neural Stimulation

3. Chronic Neural Stimulation

4. Phenotypic Selection of Magnetospirillum magneticum (AMB-1) Over-Producers using Magnetic Ratcheting

5. Magnetic Microfluidic Separation for Estimating the Magnetic Contents of Magnetotactic Bacteria

6. Outlook for Magnetic Neural Stimulation Techniques

Appendix

O autorze

Andy Kah Ping Tay received his PhD in Bioengineering from the University of California, Los Angeles. He has published over 20 articles, with more under review, and is the recipient of 7 academic awards in 2017 alone, including the SciFinder® Future Leaders Program from the American Chemical Society, and the TUM Postdoc Mobility Grant from Technical University of Munich.

Blurb

This book describes the tools, developed by the author, for perturbing endogenous mechano-sensitive ion channels for magneto-mechanical neuro-modulation. He explores the ways in which these tools compare against existing ones such as electricity, chemicals, optogenetics, and techniques like thermos/magneto-genetics. The author also reports on two platforms—magnetic ratcheting and magnetic microfluidics for directed evolution and high throughput culture of magnetotactic bacteria—that produce high quality magnetic nanoparticles for biomedical applications like neural stimulations. This thesis was submitted to and approved by the University of California, Los Angeles.

• Introduces technology for non-invasive control of neural activities that offer deep tissue penetration and controllable dosage;
  
• Examines the effects of biomechanical forces on cellular functions;
• Explores how to improve the reproducibility and uptake of magnetic tools for non-invasive neural modulation.