Acute Promyelocytic Leukemia: A Clinical Guide

ISBN-13: 9783030097134 / Angielski / Miękka / 2019 / 274 str.

Oussama Abla; Francesco Lo Coco; Miguel A. Sanz

Recenzje

"This is a clinical guide to acute promyelocytic leukemia or APL, and it is the first book dedicated entirely to APL. Starting with an engaging historical account, the book provides a comprehensive overview of the clinical and basic aspects of APL, once regarded as the most fatal type of acute myeloid leukemia, but now considered the most curable. ... general practitioners and trainees also will find this book worth exploring ... ." (Ravi Salgia, Doody's Book Reviews, January 04, 2019)

Spis treści

1 History of APL

Laurent Degos

 

2 Molecular Targets of Treatment in APL

Ramy Rahmé, Cécile Esnault, Hugues de Thé

3 The Leukemic Stem Cell

Thalia Vlachou, Giulia De Conti, Anna Giulia Sanarico, Pier Giuseppe Pelicci

4 The Molecular Genetics of APL

Lourdes Mendez, Ming Chen, Pier Paolo Pandolfi

5 APL Coagulopathy

Anna Falanga, Laura Russo, Pau Montesinos

6 Early Death in APL

Sören Lehmann

7 Prognostic Factors in APL

Javier de la Serna, Pau Montesinos, Miguel A. Sanz

8 First-line therapy for APL: Chemotherapy-based approach 

Aaron D. Goldberg, Martin S. Tallman

9 First-line Therapy: ATRA-ATO/Reduced Chemotherapy Approach

Harry Iland

10 Cure of APL without Chemotherapy

Mary-Elizabeth M. Percival, Elihu H. Estey

11 Minimal Residual Disease in APL

Laura Cicconi, Eva Barragàn

12 Treatment of refractory and relapsed APL

Eva Lengfelder

13 Hematopoietic Stem Cell Transplantation in APL

Jaime Sanz, Miguel A. Sanz

14 APL in Children

Matthew A. Kutny, Anna Maria Testi

15 Management of APL in the Elderly

Ramy Rahmé, Lionel Adès, Pierre Fenaux

16 Special Situations in APL

Massimo Breccia, Gloria Iacoboni, Miguel A. Sanz

17 APL in Developing Countries: A Chemotherapy-Based Approach

Luisa Corrêa de Araújo Koury, Raul Ribeiro, Eduardo M. Rego

18 APL in Developing Countries: ATO based Approach

Vikram Mathews

19 Therapy-Related APL

Kristen Pettit

, Richard A. Larson

20 Rare Acute Leukemia Variants involving Retinoic Acid Receptor Genes

Laura Cicconi, Oussama Abla

21 Management of Treatment-Related Complications in APL

Ombretta Annibali, Giuseppe Avvisati

O autorze

Oussama Abla, MD

The Hospital for Sick Children and University of Toronto

Division of Hematology/Oncology

Toronto, ON

Canada

 

Francesco Lo-Coco, MD

Professor of Hematology

University of Tor Vergata

Rome

Italy

 

Miguel A. Sanz, MD

Centro de Investigación Biomédica en Red de Cáncer

Madrid

Spain

Blurb

This book provides a comprehensive overview on the clinical issues and biology of acute promyelocytic leukemia (APL) and on the molecular mechanisms of targeted therapy with ATRA and ATO. The text covers major topics such as the pathophysiology of APL coagulopathy, biologic and clinical differences between children and adults with APL, and the role of minimal residual disease monitoring. Additionally, the book summarizes historical, current, and future treatment strategies in both adults and children, while highlighting the most recent therapeutic recommendations for relapsed disease and the evolving indications for autologous and allogeneic stem cell transplant. This volume also features chapters focusing on secondary APL and therapy, late effects, rare presentations such as APL in the elderly and during pregnancy, and rare APL variants that may represent therapeutic challenges.

Written by top experts in the field, Acute Promyelocytic Leukemia: A Clinical Guide is a valuable resource for clinicians and researchers who treat and investigate this disease in children and adults.