Acute Neuronal Injury: The Role of Excitotoxic Programmed Cell Death Mechanisms

ISBN-13: 9783030084684 / Angielski / Miękka / 2018 / 215 str.

Denson G. Fujikawa

Opis

This book sets out to explain the clinically relevant basic mechanisms of excitotoxic neuronal death, which in the adult mammalian brain is morphologically necrotic, not apoptotic, and which involve caspase-independent mechanisms of programmed cell death.

Spis treści

Chapter 1            Introduction       Denson G. Fujikawa

General considerations

Chapter 2            Excitotoxic programmed cell death involves caspase-independent mechanisms Ted M. Dawson and Valina L. Dawson

Chapter 3            To survive or to die: how neurons deal with it     Yubin Wang, Xiaoning Bi and Michel Baudry

Traumatic Brain Injury

Chapter 4            Oxidative damage mechanisms in traumatic brain injury and antioxidant neuroprotective approaches                Edward D. Hall, Indrapal N. Singh and John E. Cebak

Chapter 5            Mitochondrial damage in traumatic CNS injury   W. Brad Hubbard, Laurie M. Davis and Patrick G. Sullivan

Chapter 6            Neuroprotective agents target molecular mechanisms of programmed cell death after traumatic brain injury    Lu-Yang Tao

Focal Cerebral Ischemia

Chapter 7            Involvement of apoptosis-inducing factor (AIF) in neuronal death following cerebral ischemia    Nikolaus Plesnila and Carsten Culmsee

Transient global cerebral ischemia

Chapter 8            Apoptosis-inducing factor translocation to nuclei after transient global ischemia                Yang Sun, Tuo Yang, Jessica Zhang, Armando P. Signore, Guodong Cao, Jun Chen and Feng Zhang

Chapter 9            Necroptosis in cerebral ischemia               Marta Vieira and Ana Luisa Carvalho

Chapter 10          Histological and elemental changes in ischemic stroke    M. Jake Pushie, Vedashree Meher, Nicole Sylvain, Huishu Hou, Annalise Kudryk, Michael B. Kelly and Roland N. Auer

Hypoglycemic neuronal injury

Chapter 11          Hypoglycemic brain damage       Roland N. Auer

Seizure-induced neuronal death

Chapter 12          Activation of caspase-independent programmed pathways in seizure-induced neuronal necrosis                Denson G. Fujikawa

Concluding Remarks       Denson G. Fujikawa

O autorze

Dr. Denson Fujikawa is an Adjunct Professor of Neurology at the David Geffen School of Medicine at UCLA, a member of the Brain Research Institute at UCLA and a Staff Neurologist at the Department of Veterans Affairs Greater Los Angeles Healthcare System. His interest in mechanisms of nerve cell death in the brain began during a two-year epilepsy research fellowship with Dr. Claude Wasterlain, from 1981 to 1983. He is a Fellow of the American Academy of Neurology and is a member of the American Epilepsy Society, American Neurological Association, International Society for Cerebral Blood Flow and Metabolism and the Society for Neuroscience.