1.Introduction: complex genetic diseases. Part 1: The Genotype / Phenotype Relationship. 2. Genetic program and self-organization. 3. The share of the environment. 4. Analogy between organisms and particles. 5. Phenotypic Plasticity. 6. Behavior. Part2: Heredity. 7. Reproduction and Phenotypic Canalization. 8. Fertilization and overlapping of genotypes. 9. Nature of canalization. 10.Canalization : experimental data. 11. Implications of canalization. 12. Canalization and instinct. Part 3: Evolution. 13. Limits to naturalselection. 14. Instinct and evolution. 15. Biological function. 16. Differentiation and phenotypic coherence. 17. Speciation. 18.Phenotypic innovation. 19. Conclusion. 20. In summary. 21. Bibliography.