A Multidisciplinary Approach to Myelin Diseases

ISBN-13: 9781475703566 / Angielski / Miękka / 2013 / 406 str.

G. Crescenzi

Opis

The present book is based on the papers presented during an inter- disciplinary meeting which was held in Rome October 27-30, 1986, at the Istituto Superiore di Sanita under the sponsorship of NATO, and with a financial contribution of the Cassa di Risparmio di Roma. The meeting was of great interest because, for the first time, a group of highly qualified scientists specializing in different fields were gathered together to discuss the problem of demyelinating diseases. In thi. context molecular biologists, immunologists, virologists, and lipid chemists could discuss with clinicians for four days every aspect of demyelinating diseases. They shared results of the more recent research with the hope that more knowledge of the myelinating process will eventually succeed in finding new treatments for these diseases. The meeting was successful, perhaps in part because discussions during lunches and dinners provided an opportunity for the exchange of new ideas. This was apparent in the discussions held after the presen- tation of each paper and was summarized in the very lively round table which was held on the last day. The editor wishes to express his thanks to the scientific committee members: N. Baumann, C. Fieschi, G. Macchi, J.M. Matthieu, K. Suzuki. It was their advice that made the choice of participants and subjects so successful. The organizer also acknowledge the organizing support of NATO in preparing these proceedings. Acknowledgments have to be offered to Dr. S. Salvati, Dr. A.M.

Spis treści

Myelin Gene Expression.- Synthesis of the Myelin Polypeptides and Mechanisms for their Association with the Membrane.- Myelin Basic Protein Gene Expression Oligodendrocyte Metabolism and Myelin Stability in the MLD Mutant Mouse.- Myelin Proteolipid Expression in Normal and Jimpy Mice.- Myelin Associated Glycoprotein and 2?, 3? Cyclic Nucleotide 3?-Phosphodiesterase during Development and in Dismyelinating Mutants.- Myelin Assembly.- Posttranslational Modification of Myelin Proteins.- Oligodendroglial Emergence and Deposition of Four Major Myelin Constituents in the Myelin Sheath during Development: an in vivo study.- Lipids and Myelination.- Specificity and Developmental Changes of an Endogenous Inhibitor of Ceramide Galactosyltransferase.- Structural Organisation and Stability of Central Nervous System Myelin.- External Factors and Myelin Assembly.- Myelinogenesis in Culture.- The Plasticity of Mature Oligodendrocytes: a Role for Substratum in Phenotype Expression.- Oligodendrocyte Development and Myelination in Serum-Free Aggregating Brain Cell Cultures.- Myelinogenesis in Primary Cultures.- Antigenic and Functional Characteristics of a Bipotential Glial Progenitor Cell in Rat Cerebellar Primary Cultures.- Immunological Aspects of Myelin Diseases.- Myelin Antigens and Demyelination.- The Role of Antibodies against Myelin Surface Antigens in Demyelination in Chronic EAE.- Risk Factors in Multiple Sclerosis-Implications for Pathogenesis.- Autoagressive T Lymphocytes Lines in Autoimmune Diseases of the Central Nervous System: Interaction of Autoimmune T Cells with Astroglia.- Suppression of Demyelinating Diseases by Synthetic Copolymers.- Immunosuppression in Experimental Allergic Encephalomyelitis.- Humoral Immunity in Multiple Sclerosis Cerebfospinal Fluid: Role of the Blood-Brain Barrier Integrity in the Detection of Intrathecally Synthesized Immunoglobulins.- Cerebrospinal Fluid Markers in Multiple Sclerosis.- Demyelinating Diseases.- Nervous System Origin of Renal Galactosylceramide in the Twitcher Mouse Mutant.- Virus Induced Slow Infections of the Central Nervous System.- Pathogenesis of VISNA.- Neurochemical Changes in White Matter of Patients with Alzheimer’s Disease.- Central Nervous System Demyelination in Herpes Simplex Virus Type 2 Infection.- Remyelination and Myelin Repair.- Myelination Capacitiy of Transplanted Oligodendrocytes.- Proliferation of Oligodendrocytes and Remyelination.- The Effect of Hipoxia on Oligodendrocytes in Primary Mouse CNS Cell Culture.- Clinical Aspects of New Discoveries.- Round Table Discussion.- Participants.