1. Introduction 2. Modeling and Theory 3. Different Instrumentation Techniques 4. Nanobiosensors 5. DNA Biosensors 6. Carbohydrate-Receptor Interactions 7. Detection of Cancer Biomarkers by SPR and Optofluidic Ring Resonance Sensors 8. Surface Plasmon Resonance Biosensors 9. Surface Plasmon Resonance Imaging Biosensors 10. Detection of Analytes by Different Instrumental Techniques 11. Detection of Analytes by Different Instrumental Techniques: Part II 12. Economics of Biosensor