1. Introduction to irritable bowel syndrome: General overview and epidemiology 2. Pathogenesis of irritable bowel syndrome 3. Irritable bowel syndrome and the brain-gut connection 4. The control of the intestinal epithelium integrity in irritable bowel syndrome patients 5. Irritable bowel syndrome and gut microbiota 6. Gender-related differences and significance of gonadal hormones in irritable bowel syndrome 7. Genetic aspect (with SNPs) of irritable bowel syndrome 8. Clinical diagnosis of irritable bowel syndrome 9. Biomarkers of irritable bowel syndrome 10. Irritable bowel syndrome: Current therapies and future perspectives 11. Pain in irritable bowel syndrome 12. Non-pharmacological approach in irritable bowel syndrome therapy 13. Diet in irritable bowel syndrome 14. Correlation of irritable bowel syndrome with psychiatric disorders 15. Preclinical models of irritable bowel syndrome