1. Overview Rod Scott and Matt Mahoney; 2. Systems biological approaches to the genetic complexity of the epilepsies Jeffrey L. Brabec, Montana Kay Lara, Anna L. Tyler and J. Matthew Mahoney; 3. Transcriptomic and epigenomic approaches for epilepsy Anika Bongaarts, Jagoda Glowacka, Konrad Wojdan, Angelika Mühlebner, Eleonora Aronica and James D. Mills; 4. Phenomenological mesoscopic models for seizure activity Maria Luisa Saggio and Viktor K. Jirsa; 5. Computational modeling approaches to epilepsy Yujiang Wang, Gabrielle Marie Schroeder, Nishant Sinha and Peter Taylor; 6. The baseline and epileptiform EEG: a complex systems approach Giridhar P. Kalamangalam and Mircea Chelaru; 7. Neuronal approaches to epilepsy Rod Scott and Matt Mahoney; 8. Mapping epileptic networks with scalp and invasive EEG: applications to epileptogenic zone localization and seizure prediction Manel Vila-Vidal and Adria Tauste Campos; 9. A neuroimaging network-level approach to drug-resistant epilepsy Niels A. Foit, Fatemeh Fadaie, Andrea Bernasconi and Neda Bernasconi; 10. Epilepsy as a complex network disorder: insights from functional MRI David Carmichael, Rory J. Piper and Fraser Aitken.