A Case-Based Guide to Neuromuscular Pathology

ISBN-13: 9783030256814 / Angielski / Miękka / 2019 / 408 str.

Lan Zhou; Dennis K. Burns; Chunyu Cai

Spis treści

Part I: Introduction to Neuromuscular Pathology Evaluation

1 Skeletal Muscle Biopsy Evaluation

Dennis K. Burns

2 Peripheral Nerve Biopsy Evaluation

Chunyu Cai

3 Skin Biopsy with Cutaneous Nerve Fiber Evaluation

Lan Zhou

Part II: Myopathy Cases

4 A 20-year-old man with acute multi-organ failure and rhabdomyolysis

Lan Zhou and Susan C. Shin

5 A 45-year-old woman with proximal limb weakness and skin peeling on fingertips

Lan Zhou, Susan C. Shin, and Chunyu Cai

6 A 75-year-old man with leg and hand weakness

Lan Zhou and Chunyu Cai

7 A 53-year-old woman with proximal limb weakness and marked CK elevation

Lan Zhou and Chunyu Cai

8 A 61-year-old woman with distal limb and deltoid weakness

Lan Zhou

9 A 63-year-old woman with debilitating muscle pain

Lan Zhou

10 A 33-year-old woman with pain and swelling in the right calf and persistent fever

Lan Zhou, Laura Stein, and Susan C. Shin

11 A 28-year-old woman with proximal limb weakness and scapular winging

Jaya R. Trivedi, Chunyu Cai, and Rahul Abhyankar

12 A 52-year-old man with proximal limb weakness and hand stiffness

Lan Zhou and Susan C. Shin

13 A 51-year-old woman with long-standing exercise intolerance

Lan Zhou

14 A 37-year-old woman with leg weakness

Elisabeth Golden and Lan Zhou

15 A 25-year-old woman with droopy eyelids and double vision

Lan Zhou and Chunyu Cai

16 A 58-year-old man with hypercapnic respiratory failure

Lan Zhou, Patrick Kwon, and Susan C. Shin

17 A 65-year-old man with asymmetrical leg weakness and foot tingling

Lan Zhou and Chunyu Cai

18 A 40-year-old man with muscle pain and fatigue

Lan Zhou

19 A 42-year-old woman with progressive limb weakness and breathing difficulty

Lan Zhou and Dennis K Burns

20 A 49-year-old man with limb weakness and skin changes

Kara Stavros, Rajeev Motiwala, Lan Zhou, and Susan C. Shin

21 A 54-year-old man with lower limb weakness

Lan Zhou

22 A 63-year-old man with progressive limb weakness and slurred speech

Lan Zhou and Susan C. Shin

23 A 6-year-old girl with muscle pain and swelling in the thighs

Diana P. Castro, Chunyu Cai, and Dustin Jacob Paul

24 A 4-year-old boy with progressive weakness, difficulty walking and running, and increased falls

Diana P. Castro, Chunyu Cai, and Dustin Jacob Paul

25 A 2-year-old girl with hypotonia since birth and delayed motor and speech development

Diana P. Castro, Chunyu Cai, Dustin Jacob Paul

26 An 8-year-old boy with delayed motor milestones and proximal leg muscle weakness

Partha S. Ghosh and Hart G. W. Lidov

27 A 6-year-old-boy with proximal leg muscle weakness and facial weakness

Partha S. Ghosh and Hart G. W. Lidov

28 A 6-week-old boy with neonatal hypotonia and feeding and respiratory difficulties

Partha S. Ghosh and Hart G. W. Lidov

29 A 6-year-old boy with respiratory and feeding difficulties at birth, delayed gross motor milestones, and facial and proximal lower limb weakness

Partha S. Ghosh and Chunyu Cai

30 A 12-year-old girl with a 2-year history of progressive weakness and difficulties with exercise

Diana P. Castro, Chunyu Cai, and Dustin Jacob Paul

31 A 3-month-old boy with generalized hypotonia, weakness, pneumonia and respiratory failure

Diana P. Castro, Chunyu Cai, and Dustin Jacob Paul

Part III: Neuropathy Cases

32 A 59-year-old woman with subacute lower limb weakness and painful paresthesia

Shaida Khan and Chunyu Cai

33 A 63-year-old man with nausea, vomiting, orthostatic dizziness, and distal limb paresthesia

Jeffrey L. Elliott, Lan Zhou, Chunyu Cai, and Michelle Kaku

34 A 47-year-old woman with progressive numbness and weakness in the limbs

Lingchao Meng, Yun Yuan, and Shan Chen

35 A 65-year-old woman with acute limb weakness and worsening of paresthesia

Susan C. Shin, Michelle Kaku, and Lan Zhou

36 A 34-year-old man with right hand and left foot numbness

Sharon P. Nations and Dennis K. Burns

37 A 64-year-old woman with progressive pain, numbness and weakness in the right lower limb

Lan Zhou, Susan Morgello, Rajeev Motiwala, and Susan C. Shin

38 A 68-year-old man with progressive lower limb numbness and weakness and urinary incontinence

Lan Zhou, Susan Morgello, and Susan C. Shin

39 A 53-year-old woman with pain, burning, tingling, and numbness in the distal limbs

Lan Zhou

40 A 40-year-old woman with patchy painful paresthesia

Lan Zhou

41 A 39-year-old woman with intermittent bilateral foot and leg pain since childhood

Ryan Castoro, Jun Li, and Lan Zhou

42 A 35-year-old man with pain and numbness in the left lateral thigh

Lan Zhou

O autorze

Lan Zhou, MD, PhD

Departments of Neurology and Pathology

Boston University Medical Center

Boston, MA 

USA

Dennis K. Burns, MD

Department of Pathology

Neuropathology Section

The University of Texas Southwestern Medical Center

Dallas, TX 

USA

Chunyu Cai, MD, PhD

Department of Pathology

The University of Texas Southwestern Medical Center

Dallas, TX 

Blurb

This book provides a practical guide to the field of neuromuscular pathology including muscle, peripheral nerve, and skin biopsies with biopsy interpretation. Divided into three parts, the book begins with introductory chapters that review muscle, nerve, and skin biopsy indications and procedures, normal muscle and nerve histology, and common muscle and nerve pathology. The 28 myopathy case chapters in Part 2 and 11 neuropathy case chapters in Part 3 illustrate the clinical and pathological features of many neuromuscular diseases, demonstrate the indications and utilities of biopsies, discuss clinical and pathological differential diagnosis, update the individual disease management, and summarize pertinent clinical and pathology pearls for each case. 

A Case-Based Guide to Neuromuscular Pathology will function as an indispensable reference for neurologists and pathologists looking to understand the utility of muscle, nerve, and skin biopsies. This book will also aid neurology residents, neuromuscular fellows and neuropathology fellows in preparing for questions related to the muscle and nerve pathology in their in-service and board exams.