A-Beta Metabolism and Alzheimer's Disease

ISBN-13: 9781587062308 / Angielski / Twarda / 2003 / 179 str.

Takaomi Comings Saido

Opis

This book provides information regarding three major aspects of Aβ metabolism: generation from its precursor, degradation within the brain, and transport out of the brain. It is useful for graduate students, post-doctoral fellows, and scientists both in this and other disciplines.

Spis treści

1. Overview—Aß Metabolism: From Alzheimer Research to Brain Aging C o n tro 2. ß-Secretase: Progress and Open Questions 3. APP a-Secretase, a Novel Target for Alzheimer Drug Therapy 4. ?-Secretase and Presenilin 5. Functional Roles of APP Secretases 6. Proteolytic Degradation of Aß by Neprilysin and Other Peptidase 7. Aß Degradation by Endothelin-Converting Enzymes 8. Aß Metabolism in Cholesterol Enriched Membrane Microdomains 9. Amyloid ß-Protein in Low-Density Membrane Domains 10. Transport-Clearance Hypothesis for Alzheimer’s Disease and Potential Therapeutic Im plication 11. Potential Role of Endogenous and Exogenous Aß Binding Molecules in Aß Clearance and M etabolism 12. Modulating Amyloid-ß Levels by Immunotherapy: A Potential Therapeutic Strategy for the Prevention and Treatm ent of Alzheimer’s Disease

O autorze

Saido, Takaomi Comings