Inflammation in the Pathogenesis of Chronic Diseases: The Cox-2 Controversy

ISBN-13: 9789048174294 / Angielski / Miękka / 2010 / 324 str.

Randall E. Harris

Opis

In this book, a worldwide panel of leading experts discuss the role of inflammation in the pathogenesis of major chronic diseases and the current controversy regarding risk versus benefit of selective cyclooxygenase-2 (COX-2) inhibitors. The authors provide exciting and enlightening perspectives on COX-2 and related molecular targets in the future of medicine, including historical perspectives.

Recenzje

From the reviews: "This is an up-to-date review of the current understanding of inflammation, the mechanisms by which it affects disease, and the role of anti-inflammatory medications pertaining to COX-2 and its inhibition. ... Physicians and researchers with a particular interest in the current research and understanding of inflammation and COX-2 inhibition are the intended readers. ... It is detailed, but written with great clarity and exhaustive references. It will be a great addition to any medical library." (Vladimir N. Despotovic, Doody's Review Service, February, 2010)

Spis treści

Preface Contributors I. Historical Perspectives CHAPTER 1. Anti-inflammatory Drugs in the 21st Century K. D. Rainsford, PhD II. Inflammatory Mechanisms of Pathogenesis CHAPTER 2. Nitric oxide synthase and cyclooxygenase interactions in cartilage and meniscus: relationships to joint physiology, arthritis, and tissue repair J. Brice Weinberg, MD, Beverley Fermor, PhD, Farshid Guilak, PhD CHAPTER 3. obesity, inflammation, and vascular disease: The Role of the Adipose Tissue as an Endocrine Organ Paolo Calabro’, MD, Edward T. H. Yeh, MD Chapter 4. COX-2 and THE Inflammogenesis of Cancer Randall E. Harris, MD, PhD CHAPTER 5. Role of COX-2 in Inflammatory AND DEGENERATIVE Brain Diseases Luisa Minghetti, PhD III. Inflammation and Cardiovascular Disease: the Coxib Controversy CHAPTER 6. Cardiovascular Effects of the Selective Cyclooxygenase-2 Inhibitors William B. White, MD CHAPTER 7. COX-2 inhibitors and Cardiovascular Risk Daniel J. Salzberg, MD, Matthew R. Weir, MD CHAPTER 8. A BIOLOGICAL RATIONALE FOR THE CARDIOTOXIC EFFECTS OF ROFECOXIB: COMPARATIVE Analysis with other COX-2 Selective Agents and NSAIDs R. Preston Mason, PhD, Mary F. Walter, PhD, Charles A. Day, Robert F. Jacob, PhD IV. COX-2 Blockade in Cancer Prevention and Therapy CHAPTER 9. Cancer Chemoprevention by COX-2 Blockade: Results of Case Control Studies. Randall E. Harris, MD, PhD, Joanne Beebe-Donk, Galal A. Alshafie, MD, PhD CHAPTER 10. Strategies for Colon Cancer Prevention: Combination of Chemopreventive Agents Bandaru S. Reddy, DVM, PhD V. Inflammation and Neurodegenerative Disease CHAPTER 11. NSAIDs FOR THE Chemoprevention of Alzheimer’s Disease Christine A. Szekely, Ph.D., Terrence Town, Ph.D, Peter P. Zandi,Ph.D CHAPTER 12. Inflammation in Parkinson’s disease: causative or epiphenomenal? Andreas Hald, PhD, Johan van Beek, PhD, and Julie Lotharius, PhD VI. Nutrition, Inflammation and Chronic Disease CHAPTER 13. NUTRITION, INFLAMMATION, AND CARDIOVASCULAR DISEASE Michel de Logeril, MD CHAPTER 14. NUTRITION, INFLAMMATION & bRAIN AGING Frances C. Lau, PhD, Barbara Shukitt-Hale, PhD, James Joseph, PhD INDEX