The Genetics of Complex Thyroid Diseases

ISBN-13: 9784431703259 / Angielski / Twarda / 2002 / 222 str.

T. Akamizu; M. Kasuga; T. F. Davies

Opis

The rapid developments in molecular genetics have clarified many of the muta tions in monogenic thyroid diseases over the last two decades; now the target of molecular thyroid genetics has become the oligogenic thyroid diseases. These include the autoimmune thyroid diseases and familial thyroid cancers, both of which are much commoner than the monogenic diseases. However, the method ological approach to the genetics of these more complex diseases is still far from being well established. Although the discovery of susceptibility genes has been partially accomplished in complex diseases such as asthma, Crohn's dis ease, and types I and II diabetes mellitus, the elucidation of susceptibility genes in complex diseases remains a major challenge. This volume contains papers presented at the International Symposium on the Genetics of Complex Thyroid Diseases. This meeting was held in association with the International Thyroid Congress in Kyoto in October 2000 and sup ported in part by the Japan Intractable Diseases Research Foundation and Knoll Pharmaceuticals Inc. The symposium was the first international symposium con cerning the genetics of complex thyroid diseases and was restricted to the study of the autoimmune thyroid diseases and familial thyroid cancer. Twenty distin guished researchers from the United States, the United Kingdom, France, Ger many, Italy, and Japan were invited. Each presentation precipitated intense dis cussion and there was much consensus during the meeting. Nevertheless, this volume will leave the reader with a clear understanding of how little we still know."

Spis treści

1 Autoimmune Thyroid Diseases.- Genetic dissection of familial autoimmune thyroid diseases using whole genome screening.- Genome screening for Graves’ disease susceptibility loci in U.K. families.- The involvement of the HLA region in genetic susceptibility to Grave s’ disease.- HLA and autoimmune thyroid diseases.- What can we learn from the genetics of diabetes?.- The genomic biology of the human chromosome 2q33 costimulatory receptor region.- CTLA-4 gene in the pathogenesis of Graves’ disease.- The evolving role of CTLA-4 in the genetic predisposition to AITD.- Association of AITD with microsatellite markers for TSHR and CTLA-4 in Japanese patients.- 2 Familial Thyroid Cancers.- Familial non medullary thyroid cancer.- Cowden disease and the PTEN/MMACI gene.- Molecular mechanisms of RET activation in human neoplasia.- Lessons from Chernobyl; need for molecular epidemiology of childhood thyroid cancer.- Genetic events in radiation-induced thyroid cancer.- Keyword Index.