Risedronate Effects on Bone Metastasis of Rat Mammary Tumor Cell Lines

ISBN-13: 9783847341529 / Angielski / Miękka / 2012 / 128 str.

Kelli Boyd;Gregory Hall;Elizabeth Howerth

Opis

When compared to MTA cells, MTB-01 cells were susceptible to risedronateinduced apoptosis, had decreased ability to bind to risedronate-treated bone, and did not produce MMP-2 or MMP-9 proteases. MTA cells were less susceptible to risedronateinduced apoptosis and produced MMP-2. Additionally, adhesion of MTA cells to bone matrix was not diminished by risedronate treatment. Our results suggest that the nonresponsive nature of the MTA cell line may be due to MMP-2 production (possibly allowing ongoing destruction of risedronate-treated bone), continued adhesion to risedronate-treated bone matrix, and decreased susceptibility to risedronate-induced apoptosis.

O autorze

Dr. Boyd received her undergraduate and DVM degrees from Mississippi State University. She completed a residency and PhD program at the University of Georgia. Her expertise is in comparative pathology with a special interest in pathology of genetically engineered mice and translational research.