Fabrication of interpenetrating polymer network hydrogel microspheres

ISBN-13: 9783843390316 / Angielski / Miękka / 2011 / 140 str.

Pradeep Kumar (University of Hyderabad India)

Opis

The present research project deals with the design of cinnarizine loaded oral controlled release mucoadhesive interpenetrating polymer network hydrogel microspheres composed of chitosan and methylcellulose and optimization of various response parameters using response surface methodology. A detailed introduction, literature review and methodology has been provided for the readers to gain an insight into the theory and practice of design of experiments. The research work involved application of several core aspects of drug delivery incorporating polymer complexes, hydrogel networks, gastroretention, bioadhesion, absorption window related to weakly basic drugs, mathematical modeling of drug release kinetics, microencapsulation processes and various optimization and characterization techniques. The high degree of prognosis (due to low values of error) obtained using response surface methodology corroborates that a two-factor central composite design is quite efficient in optimizing drug delivery systems that exhibit nonlinearity in response(s). The results indicated that interpenetrating polymer networks could be employed as potential gastroretentive systems for weakly basic drugs.

O autorze

Pradeep Kumar, born in Bhiwani, India (1983), received his Master in Pharmacy (Pharmaceutics) degree from GJUS&T, Hisar, India. His research interests include synthesis, characterization and modelling of biomaterials for drug delivery and tissue engineering applications. He has more than 30 publications and 20 conference proceedings to his credit.