The Genetics of Coeliac Disease in Malta

ISBN-13: 9783838367422 / Angielski / Miękka / 2010 / 112 str.

Joseph Borg;Angela A Xuereb Christopher Vidal;Christian A Scerri

Opis

Two polymorphisms found within the CTLA4 gene were studied amongst a sample of coeliac patients and cord blood DNA samples that acted as the control group. Polymorphisms within the CTLA4 gene have been associated with other autoimmune conditions and the gene plays a very important role in immuno-regulatory function. The coeliac individuals and cord blood samples were genotyped for the -318 C/T and +49 A/G single nucleotide polymorphisms. No association of the single polymorphisms or the combined haplotypes with the coeliac condition was apparent amongst the coeliac patients under study. The -318 C allele and the +49 A allele were in linkage disequilibrium amongst the cord blood samples.

O autorze

Dr. Joseph Borg B.Sc M.Sc PhD works as a research scientist at the Laboratory of Molecular Genetics, University of Malta. The work presented here is the first study on complex disease genetics of Coeliac Disease in Malta. It also laid the foundation for a large collection of family patients and relatives with Coeliac Disease.