Molecular Optimization of Calcineurin Inhibitors for Prion Disease

ISBN-13: 9783659158957 / Angielski / Miękka / 2012 / 80 str.

Saumya Patel; S. Prasanth Kumar; Yogesh T. Jasrai

Opis

This study mainly emphasizes on pharmacophore features available in the immunosuppressant drugs, especially Calcineurin inhibitors for human prion diseases. The structural and functional properties of FK506/Tacrolimus - a drug used for treatment of human prion diseases were enhanced through pharmacophore-assisted molecular optimization approach. Important pharmacophore features responsible for interaction with active site and intramolecular structural stability were elucidated.

O autorze

Saumya K. Patel, a budding Bioinformatician engaged in development of antimalarial and anticancer compounds and proves its efficacy in wet-lab experiments. He chosen his career in Ph.D. Bioinformatics after the completion of graduation in Biochemistry and post-graduation in Bioinformatics.He has also published research articles in reputed journals.