Role of Apoptosis in Infection

ISBN-13: 9783642061929 / Angielski / Miękka / 2010 / 296 str.

Diane E. Griffin

Opis

This mechanism of programmed cell death plays an important role in normal development and control of cell numbers in mature animals. Initiation of the apoptotic process can come from external or internal stimuli and is highly regulated both by molecules that facilitate and by molecules that inhibit the process. It can be envisioned that apoptosis as a response to an intracellular pathogen is a useful way for the host to eliminate infected cells, decreasing the likelihood of spread of the infection to neighboring cells and preventing pathogen persistence. Alternatively, the apoptotic response may be a major mechanism by which the host is harmed by a pathogen.

Spis treści

Viral infections.- Mechanisms and importance of apoptosis during reovirus infections.-Poliovirus, pathogenesis of poliomyelitis and apoptosis.- Neuronal Cell Death in Alphavirus Encephalomyelitis.- HSV-Induced Apoptosis in Herpes Encephalitis.- The role of apoptosis in defense against baculovirus infection in insects.- Bacterial infections.- The role of host cell death in Salmonella infections.- Role of macrophage apoptosis in Yersinia pathogenesis.- Parasitic infections.- Entamoeba histolytica activates host cell caspases during contact-dependent cell killing.- Interactions between malaria and mosquitoes: the role of apoptosis in parasite establishment and vector response to infection.- Apoptosis and its modulation during infection with Toxoplasma gondii: Molecular mechanisms and role in pathogenesis.- Immune responses.- Modulation of the immune response in the nervous system by rabies virus.- Apoptotic cells at the crossroads of tolerance and immunity.- Subject index

O autorze

Diane E. Griffin, Professor, Department Chair, PhD and MD, Stanford University, 1968, Molecular Microbiology and Immunology