Pediatric Hypertension

ISBN-13: 9783031062308 / Angielski / Twarda / 2023 / 957 str.

Joseph T. Flynn; Julie R. Ingelfinger; Tammy M. Brady

Opis

For the past 17 years, Pediatric Hypertension has served as the definitive reference text on hypertension in children and adolescents. Each edition has incorporated the latest research on the pathophysiology, clinical significance and management of hypertension in the young, and has incorporated the most current consensus guidelines on diagnosis and management. The years since publication of the fourth edition have seen further advances in the field that merit publication of an updated, expanded text, including:

•      Analysis of the implications of updated hypertension guidelines on identification of youth at highest cardiovascular risk
•      Additional data on the proximate effects of high blood pressure in children in adolescents
•      Further understanding of the links between high blood pressure in youth and surrogate markers of adult cardiovascular disease

The fifth edition is a readable, informative text that provides a comprehensive guide to the diagnosis, management and therapy of hypertension in children and adolescents, and presents new data that very clearly indicate that the origins of adult cardiovascular disease are rooted in pediatric hypertension. It will, as a result, be very important for therapeutic decisions and will also be highly relevant for those in internal medicine, who care for the millions of adults who have hypertension, cardiovascular disease and kidney disease. In this sense, the book fulfills the longstanding goal of showing that hypertension that begins in childhood is important to track, diagnose and treat, and that the present understanding of adult hypertension necessitates the study of blood pressure in youth.The fifth edition has a similar structural format to the prior editions and covers all aspects of pediatric hypertension, from basic science research to the most recent clinical information.

Spis treści

Section I. Regulation of Blood Pressure and Pathophysiologic Mechanisms of Hypertension   

1. Neurohumoral and Autonomic Regulation of Blood Pressure
2. Vasoactive Factors and Blood Pressure in Children
3. Cardiovascular Influences on Blood Pressure
4. Ions and Fluid Dynamics in Hypertension
5. Uric Acid in the Pathogenesis of Hypertension
6. Insulin Resistance and Other Mechanisms of Obesity Hypertension
7. Monogenic and Polygenic Contributions to Hypertension
8. Perinatal Programming and Blood Pressure
9. Heritability and Familial Aggregation of Blood Pressure
10. The Role of Dietary Electrolytes and Childhood Blood Pressure Regulation
11. Endothelial Dysfunction and Vascular Remodeling in Hypertension
12. Early life stress and blood pressure
13. Salt Sensitivity in Childhood Hypertension
14. Early vascular aging in childhood hypertension                                                                                                                                                       Section II. Assessment of Blood Pressure in Children: Measurement, Normative Data, Epidemiology
15. Methodology of Casual Blood Pressure Measurement
16. Value of Routine Screening for Hypertension in Childhood
17. Development of Blood Pressure Norms and Definition of Hypertension in Children
18. Ambulatory Blood Pressure Monitoring Methodology and Norms in Children
19. Methodology and Applicability of Home Blood Pressure Monitoring in Children and Adolescents
20. Epidemiology of Hypertension and CVD in Children                                                                                                                                                 Section III.  Hypertension in Children: Etiologies and Special Populations      
21. Ethnic Differences in Childhood Blood Pressure
22. Obesity Hypertension: Clinical Aspects
23. Hypertension in Children with Type 2 Diabetes or the Metabolic Syndrome
24. Primary Hypertension in Children
25. White Coat Hypertension
26. Hypertension in Chronic Kidney Disease
27. Hypertension in End-Stage Renal Disease: Dialysis
28. Hypertension in End-Stage Renal Disease: Transplantation
29. Renovascular Hypertension, Vasculitis and Aortic Coarctation
30. Endocrine Hypertension
31. Neonatal and Infant Hypertension
32. Sleep Apnea and Hypertension
33. Hypertension in the Pregnant Teenager
34. Cognitive and Behavioral Aspects of Childhood Hypertension
35. Stroke and Childhood hypertension
36. Substance-Induced Hypertension: Mechanisms and Management
37. Hypertension in Oncology and Stem-cell Transplant Patients
38. Hypertension in Older Adolescents and Young Adults
39. Hypertension in the Developing World                                                                                                                                                                     Section IV.  Evaluation and Management of Pediatric Hypertension     
40. Diagnostic Evaluation of Pediatric Hypertension
41. Sequelae of Hypertension in Children and Adolescents
42. Cardiovascular Assessment of Childhood Hypertension
43. The Role of ABPM in Evaluation of Hypertensive Target-Organ Damage
44. Exercise Testing in Hypertension and Hypertension in Athletes
45. Nonpharmacologic Treatment of Pediatric Hypertension
46. Pharmacologic Treatment of Pediatric Hypertension
47. Management of Hypertensive Emergencies
48. Hypertension Care during Emergencies and Pandemics                                                                                                                                         Section V. Hypertension Research in Pediatrics 
49. Hypertensive Models and Their Relevance to Pediatric Hypertension
50. Cohort Studies, Meta-analyses, and Clinical Trials in Childhood Hypertension
51. Changes in Drug Development Regulations and Their Impact on Clinical Trials

O autorze

Dr. Joseph T. Flynn MD, MS is the Dr. Robert O. Hickman Endowed Chair in Pediatric Nephrology; Professor of Pediatrics, University of Washington; and Chief, Division of Nephrology, Seattle Children's Hospital. He is an internationally recognized expert in the treatment of hypertension in children, and recently chaired the American Academy of Pediatrics Subcommittee that developed the updated clinical practice guideline on high blood pressure in children and adolescents. Dr. Flynn served on the Council of the International Pediatric Nephrology Association from 2010-2019, and also on the Council of the American Society of Pediatric Nephrology, including 2 years as ASPN President (2012-14). He currently is a Board Member of the Renal Physicians Association and a member of the Nephrology sub-board of the American Board of Pediatrics. He currently serves as one of the Editors-in-Chief of the journal Pediatric Nephrology and is a member of the editorial boards of Hypertension, Blood Pressure Monitoring and The Journal of Pediatrics. He has contributed chapters to all five editions of the Pediatric Hypertension and edited the three previous editions.

Julie R. Ingelfinger MD is professor of pediatrics at Harvard Medical School, senior consultant in pediatric nephrology at Mass General for Children at MGB, and Deputy Editor of the New England Journal of Medicine. She is an internationally recognized hypertension specialist and consultative pediatric nephrologist. Her commitment to teaching has been reflected by receiving the Henry L. Barnett award from the AAP in 2009, the Founders Award from the American Society of Pediatric Nephrology in 2012, the National Kidney Foundation’s Honors Award in 2018, the Alumni Lifetime Achievement Award from Albert Einstein College of Medicine (2018), and the Barbara T. Murphy Award from the American Society of Nephrology (2022).

Dr. Ingelfinger has been involved in studies of the intrarenal renin angiotensin aldosterone system (RAAS) for many years. Her current projects focus on the role of the intrarenal renin angiotensin system in disease states and the role of maternal diabetes in kidney development and perinatal programming.

She is interested in innovative ways to teach writing and communication and has been an editor of Pediatric Hypertension in each of its five editions.

Dr. Tammy M. Brady MD, PhD is Associate Professor of Pediatrics at Johns Hopkins University School of Medicine where she serves as Vice Chair for Clinical Research and as the Associate Director of the Welch Center for Prevention, Epidemiology and Clinical Research. She has focused her career on improving the care of children at increased cardiovascular disease risk through research and clinical innovation. She

serves as the Medical Director of the Harriet Lane Kidney Center Pediatric Hypertension Program, and she directs a multidisciplinary obesity hypertension clinic (ReNEW clinic; Reversing the Negative cardiovascular Effects of Weight). Dr. Brady is an expert in blood pressure measurement and blood pressure device validation. She is the co-chair of the Association for the Advancement of Medical Instrumentation (AAMI) Sphygmomanometer committee, the American professional society that develops American National Standards and technical reports regarding sphygmomanometer devices. She was Chair of a two-day meeting at the WHO where published guidance and specifications on blood pressure measuring devices were updated. She is also Co-chair of the American Medical Association’s Validated Device Listing Committee.