Leprosy and Buruli Ulcer: A Practical Guide

ISBN-13: 9783030897031 / Angielski / Twarda / 2022 / 570 str.

Enrico Nunzi;Cesare Massone;Francoise Portaels

Opis

A highly disabling infectious disease in developing countries, leprosy, or Hansen's disease, is caused by Mycobacterium leprae, and is still very relevant for the human community due to its transmissible nature, variable presentation and composite clinical picture. Early identification of leprosy and Buruli ulcer (also caused by a Mycobacterium, M. ulcerans) is critical to prevent spreading and patient disability and to establish appropriate therapy. This richly illustrated, completely revised second edition of Leprosy and Buruli Ulcer describes the characteristic signs of both these diseases, and contents include abnormalities of the skin, nerves, eyes, hands, feet, testes and bone. It also presents the latest diagnostic tools to identify and quantify organ damage to enable readers to recognize and treat this composite systemic disorder, which can represent a true medical emergency if affecting eyes, nerves, and kidneys. Further, it includes additional chapters on leprosy in childhood, prophylaxis and vaccines. For both leprosy and Buruli ulcer, this handy guide helps practitioners and nursing personnel to spot the different clinical manifestations, make a prompt diagnosis and apply effective treatment of both these diseases.

Spis treści

Foreword (Roch Christian Johnson)

Preface  

Part I   Leprosy: General Section

1.      History and Phylogeography of Leprosy

2.      Microbiology of Mycobacterium leprae

3.      Genetics of Leprosy

4.      Host Response to Mycobacterium leprae

5.      Pathogenesis of Leprosy

6.      Classification of Leprosy

Part II Leprosy: Patient’s Examination

7.      Leprosy Patient History

8.      Laboratory  Investigations in Leprosy

Part III Skin

9.      Physical Examination in Leprosy: Skin

10.   Clinical Features of Leprosy

11.   Lucio–Latapí Leprosy

12.   Histopathology of the Skin in Leprosy [FP1] 

13.   Differential Diagnosis of Leprosy: Skin

Part IV  Leprosy and Nerves

14.   Peripheral Nerves in Leprosy

15.   The Leprosy Neuropathy

16.   Primary Neural Leprosy

17.   Chronic Neuropathic Pain in Leprosy

18.   Electrodiagnostic Studies in Leprosy

19.   Imaging in Leprosy

20.   Differential Diagnosis of Leprosy: Nerves

Part V   Reactions in Leprosy

21.   Reactions in Leprosy

22.   Lucio’s Phenomenon in Leprosy

Part VI  Leprosy: Systemic Involvement

23.   Ocular Involvement in Leprosy

24.   Otolaryngological Manifestations of Leprosy

25.   Other Organs involved in Leprosy

Part VII Patient’s Management in Leprosy

26.   Diagnostic Work-Up of Leprosy

27.   Drugs in Leprosy

28.   Treatment and Prophylaxis of Leprosy

29.   Prognosis of Leprosy

30.   Neurolysis in Leprosy

31.   Prevention of Disability and Ulcer Care in Leprosy

32.  Surgical and Social Rehabilitation in Leprosy

Part VIII   Leprosy and Community

33.   Leprosy in Pregnancy

34.   Leprosy in Childhood

      35.   Leprosy and HIV/AIDS Co-infection

36.   Epidemiology  of  Leprosy

37.   Leprosy Control

38. The Leprosy Mailing List

Part IX    Buruli Ulcer: General Section

39.   History and geographic distribution of Buruli ulcer

40.   Microbiology of Mycobacterium ulcerans

Part X    Buruli Ulcer: Patient’s Examination

41.   Laboratory Investigations in Buruli ulcer   

42.   Clinical Features of Buruli ulcer

43.   Differential Diagnosis of Buruli ulcer             

Part XI    Buruli Ulcer: Patient’s Management

44.   Diagnostic Work-up of Buruli ulcer

45.  Treatment of Buruli ulcer

46.   Rehabilitation in Buruli ulcer

Part XII    Buruli Ulcer and Community

47.   Epidemiology of Buruli ulcer

48.    Buruli ulcer Control

Subject Index

 

O autorze

Professor Enrico Nunzi graduated with honors and specialized in dermatology and syphilography, medical microbiology, dermatology and tropical medicine at the University of Genoa (Italy). He has been Director of the Institute of Dermatology at Loja Technical University Hospital (Ecuador) since 2012. Before that he was Director of the Social Dermatology Unit at S.Martino Hospital and of the Skin Immunopathology Service. Author of over 130 publications in Italian and Spanish, he has worked for the governmental health services of the Democratic Republic of Congo as the Medical Director of the health sector at Kimbau Hospital, as a Research Fellow at the Dermatology Department of the University of Amsterdam, and as Director of the Genoa University Postgrad School of Leprology and Tropical Dermatology.

Cesare Massone is an Associate Professor of Dermatology and Venereology, and Medical Director of the Dermatology Unit-Ospedali Galliera in Genova, Italy. After graduating with honors and receiving board certification, he was made an Associate Professor of Dermatology at the Medical University of Graz. His areas of research interest include dermoscopy and melanoma, cutaneous lymphomas, leprosy & tropical dermatology, psoriasis & biologicals therapies, dermatopathology, and teledermatology. Dr. Massone is the author of over 200 publications, including books (WoS HI 34). Regularly presenting at international congresses, he was awarded the Pathnet grant from the French Ministry for Research, and the AESCA Award of the Austrian Society of Dermatology in 2005.

Professor Françoise Portaels was Head of the Mycobacteriology Unit, Department of Microbiology, Institute of Tropical Medicine (Belgium). Her areas of expertise include microbiology and epidemiology. She is a Professor Emeritus of the Free University of Brussels (VUB), Belgium and of the Institute of Tropical Medicine Antwerp, Belgium and has a extensive experience in teaching and heading lab research. Member of various academies and societies, including the  International Union Against Tuberculosis (UNION), Belgian Royal Academy of Medicine, Belgian Royal Academy of Oversees Sciences and the American Society of Tropical Medicine and Hygiene. She was awarded the Follereau-Damien and the American Society of Tropical Medicine prizes. She has authored over 400 publications and edited 5 books (WoS HI 32), and has participated in countless field activities, international courses and missions.