Chordoma of the Spine: A Comprehensive Review

ISBN-13: 9783030762001 / Angielski / Twarda / 2021 / 307 str.

Daniel M. Sciubba; Joseph H. Schwab

Spis treści

Section I Pathophysiology and Molecular Mechanisms of Chordoma

1 Notochordal Morphogenesis and the Origin of Chordoma

Matthew L. Goodwin, MD PhD, David C. Clever, MD PhD

2 Molecular and Genetic Mechanisms of Spinal Chordoma

Connor Liu, BS; Ann Liu, MD; Chetan Bettegowda, MD/PhD

Section II Epidemiology, Clinical History, and Work-Up for Chordoma

3 Historical Overview, Demographics, and Clinical Presentation of Spinal Chordoma

Zach Pennington BS, Andrew Schilling AB, Joseph H. Schwab MS MS, Daniel M. Sciubba MD

4 Clinical Work up, Diagnostic Imaging and Biopsy

Daniel Ryan, MD; John Gross, MD; Zach Pennington BS, Majid Khan, MD

5 Histopathologic Classification of Spinal Chordoma

John M Gross MD, Edward F McCarthy MD

6 Multi-disciplinary Planning for Treatment

Nicholas A Shepard MD, Matthew W Colman MD

Section III Surgical Management of Chordoma

7 Surgical Management of Chordoma of the Occipitocervical Junction

Zach Pennington BS, Jeff Ehresman BS, Andrew Schilling BA, Daniel M. Sciubba MD

8 Surgical Management of Chordoma of the Cervical Spine

Oliver G.S. Ayling MD, MSc, Nicolas Dea MD, MSc

9 Surgical Management of Chordoma of the Thoracic Spine

Daniel G. Tobert MD, John H. Shin MD, Joseph H. Schwab MD

10 Surgical Management of Chordoma of the Lumbar Spine

Sutipat Pairojboriboon MD, Amanda Sacino MDPhD, Sheng-fu Larry Lo MD

11 Surgical Management of Chordoma of the Sacrum

Peter S. Rose, MD, Matthew T. Houdek, MD, Cory G. Couch, MD

12 Soft Tissue Reconstruction Following Surgery for Sacral Chordoma

Rachel Skladman MD, Zach Pennington BS, Justin M. Sacks MD MBA FACS

13 Vascular Reconstruction After EnBloc Resection.

Daniel G. Tobert MD, Joseph H. Schwab MD

Section IV Radiation and Chemotherapeutic Adjuvants for Chordoma

14 Photon Therapy for Chordoma of the Spine

Chunzi Jenny Jin MD MSc, Yoshiya Josh Yamada MD FRCPC

15 Heavy Particle Therapy for Chordoma

David J. Konieczkowski MD PhD, Reiko Imai MD, Thomas F. DeLaney MD

16 Systemic Therapy, Trials and Future Directions for Chordoma of the Spine

Daniel J. Zabransky, MD, PhD, Zach Pennington BS, Christian Meyer, MD, MS, PhD

Index

O autorze

Daniel M. Sciubba
Department of Neurosurgery
Zucker School of Medicine at Hofstra University/Northwell Health
Manhasset, NY
USA

Joseph H. Schwab
Department of Orthopaedic Surgery
Massachusetts General Hospital
Harvard Medical School
Boston, MA
USA

Blurb

This book provides a comprehensive review of the epidemiology, pathogenesis, diagnosis, and management of chordomas of the mobile spine and sacrum. Historically, knowledge about how to deliver such state-of-the-art care has not been widespread, resulting in inconsistent treatment, and, all too often, suboptimal outcomes for chordoma patients. This text is an important step towards broadening that knowledge, and, in turn, improving the care provided to chordoma patients. The book is divided into 4 parts comprising 16 chapters. The first part focuses on the pathophysiology and molecular drivers of chordoma. The second focuses on the epidemiology and clinical history, as well as the histological, oncologic, and radiographic work-up of chordoma. The third part focuses primarily on the technical aspects of surgery for chordoma. It is broken down by anatomic region, with the final two chapters focusing on the soft tissue and bony reconstruction following chordoma resection. The last part focuses on the exciting field of adjuvant therapies for chordoma. This includes both radiation therapies and novel chemotherapeutic options for recurrent, metastatic, and dedifferentiated chordoma.

 

Written by world experts from leading chordoma centers, Chordoma of the Spine serves as a valuable reference for spinal oncologists and general spine surgeons who may encounter chordoma patients in their practice. It provides the most up-to-date evidence regarding all aspects of treating patients with this disease. By focusing on this specific pathology of the spine, this resource condenses expert-level research into understandable treatment algorithms.