The Molecular Basis of Human Cancer

ISBN-13: 9781934115183 / Angielski / Twarda / 2016 / 873 str.

William B. Coleman

Opis

This book covers the concepts of molecular medicine and personalized medicine.

Spis treści

Chapter 1

Cancer Epidemiology: Incidence and Etiology of Human Neoplasms

William B. Coleman and Gregory J. Tsongalis

Chapter 2

Essential Concepts and Techniques in Molecular Biology

Claudine L. Lefferts, PhD and Joel A. Lefferts, PhD

Chapter 3

Cancer Genomics

Jonathan R. Pollack

Chapter 4

Cancer Cytogenetics

Thomas Ried, Kerstin Heselmeyer-Haddad, Jordi Camps, and Timo Gaiser

Chapter 5

The Epigenetic Basis of Human Cancer

Thomas Mikeska and Alexander Dobrovic

Chapter 6

Cancer Proteomics

Jeffrey M. Lake and Timothy D. Veenstra

Chapter 7

An Overview of Cancer Genes

Ashley G. Rivenbark, PhD

Chapter 8

Oncogenes and the Initiation and Maintenance of Tumorigenesis

Dean W. Felsher, Constadina Arvanitis, Pavan Bendapudi, and Pavan Bachireddy

Chapter 9

Positive Mediators of Cell Proliferation in Neoplasia: Growth Factors and Receptors

Luca Grumolato, Ph.D. and Stuart Aaronson, M.D.

Chapter 10

Senescence, Apoptosis, and Cancer

Manjari Dimri and Goberdhan P. Dimri

Chapter 11

Novel Cancer Therapies Targeting Angiogenesis

Monte Willis and Nancy Klauber-DeMore

Chapter 12

Beyond the Primary Tumor: Progression, Invasion, and Metastasis

Danny R. Welch, Ph.D. and Douglas R. Hurst, Ph.D.

Chapter 13

Simple Sequence Mutations

Christophe Béroud and Mireille Claustres

Chapter 14

Single Nucleotide Polymorphisms and Cancer Susceptibility

Richard A. Hubner and Richard S. Houlston

Chapter 16Chromosomes and Chromosomal Instability in Human Cancer

Kazuma Ohyashiki, Masahiko Kuroda, and Junko H. Ohyashiki

Chapter 17

Epigenetic Mechanisms in Cancer Development

José Ignacio Martín-Subero and Manel Esteller

Chapter 18

MicroRNAs and Cancer

Phong Trang, Joanne Weidhaas, and Frank J. Slack

Chapter 19

Erionite and Asbestos in the Pathogenesis of Human Malignant Mesotheliomas

Mutlay Sayan and Brooke T. Mossman

Chapter 20

Viral Mechanisms in Human Carcinogenesis

Paul F. Lambert, PhD

Chapter 21

Hormonal Carcinogenesis: The Role of Estrogens

William A. Ricke, Karin Williams, Jalissa Wynder, Ganesh Palapattu, Yuzhuo Wang, Gerald R. Cunha

Chapter 22

Sporadic Cancers

Clemens B. Tempfer and Marc-André Reymond

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Chapter 23

Hereditary Cancer

Zoran Gatalica, MD, DSc, Anatole Ghazalpour, PhD Stan L. Lilleberg, PhD, Jeffrey Swensen, PhD, and Henry T. Lynch, MD

Chapter 24

Retinoblastoma:  Clinical and Molecular Perspectives

Justis P. Ehlers MD and J. William Harbour MD

Chapter 25

Xeroderma Pigmentosum and the DNA Damage Response to Ultraviolet Light

James E. Cleaver

Chapter 26

Hereditary Colorectal Cancer

Sonia S. Kupfer and Nathan A. Ellis

Chapter 27

Lungs

Michael P. Lux, Mayada R. Bani, Peter A. Fasching, and Matthias W. Beckmann

Chapter 28

The Molecular Basis of Prostate Carcinogenesis

Smitha Dutt and Allen C. Gao

Chapter 29

Molecular Basis of Lung Carcinogenesis

Kwun M. Fong, Jill E. Larsen, Casey Wright, Krishna Sriram, Morgan Davidson, Marissa Daniels, Yoshitaka Sekido, Rayleen V. Bowman, Ian A. Yang, and John D. Minna

Chapter 30

The Molecular Basis of Skin Carcinogenesis

Alessia Pacifico, MD, Giovanni Leone, MD, Honnavara N. Ananthaswamy, PhD

Chapter 31

The Molecular Biology of Leukemias

L. Jeffrey Medeiros and Sergej N. Konoplev

Chapter 32

Molecular Mechanisms in Non-Hodgkin Lymphoma

John Hunt, MD, Yuri Fedoriw, MD and William N. Rezuke, Jr., MD

Chapter 33

The Molecular Pathology of Head and Neck Squamous Cell Carcinoma

Laura J. Tafe

Chapter 34

Ovarian Cancer

Amy D. Brockmeyer and Louis Dubeau, MD, PhD

Chapter 35

Molecular Pathology of Bone and Soft Tissue Tumors

José Luis Ordóñez PhD, Daniel Osuna PhD, Juan Madoz-Gúrpide PhD, Enrique de Álava, MD, PhD

Chapter 36

The Molecular Biology of Human Brain Tumors

Daniel Coluccia, Adrienne Weeks, Javier Fandino, Christian Schneider, Christian Smith, and James T. Rutka

Chapter 37

Cancer Drug Discovery and Anticancer Drug Development

James Turkson, PhD

Chapter 38

Heart

Zhuo (Georgia) Chen, PhD, Suresh Ramalingam, MD, and Dong M. Shin, MD

Chapter 39

Targeting Oncoproteins for Molecular Cancer Therapy

Joshua E. Allen and Wafik S. El-Deiry

Chapter 40

Therapeutic Agents that Inhibit Angiogenesis

Francesco Torino, Roberta Sarmiento, Raffaelle Longo, and Giampietro Gasparini

Chapter 41

Small Molecule Inhibitors

Xin Chen, Ph.D. and Jian Jin, Ph.D

Chapter 42

Molecular Detection and Diagnosis of Cancer

Christos Patriotis, Padma Maruvada, and Sudhir Srivastava

Chapter 43

Gene Therapy in the Treatment of Human Cancer

Anand C. Annan, MBBS, Paul B. Fisher, MPh, PhD, Paul Dent, PhD, Gene P. Siegal, MD, PhD, David T. Curiel, MD, PhD

Chapter 44

Personalized Medicine for the Treatment of Human Cancer

Scott A. Turner, PhD and Gregory J. Tsongalis, PhD

O autorze

William B. Coleman

Department of Pathology and Laboratory medicine, Curriculum in 

Toxicology, Program in Translational Medicine, UNC Lineberger 

Comprehensive Center, University of North Carolina School of Medicine, 

Chapel Hill, NC

Blurb

This book covers the concepts of molecular medicine and personalized medicine. Subsequent chapters cover the topics of genomics, transcriptomics, epigenomics, and proteomics, as the tools of molecular pathology and foundations of molecular medicine. These chapters are followed by a series of chapters that provide overviews of molecular medicine as applied broadly to neoplastic, genetic, and infectious diseases, as well as a chapter on molecular diagnostics. The volume concludes with a chapter that delves into the promise of molecular medicine in the personalized treatment of patients with complex diseases, along with a discussion of the challenges and obstacles to personalized patient care.

The Molecular Basis of Human Cancer, Second Edition, is a valuable resource for oncologists, researchers, and all medical professionals who work with cancer.