Venous Thrombosis : From Genes to Clinical Medicine

ISBN-13: 9781872748948 / Angielski / Twarda / 1997 / 368 str.

D.N. Cooper and M. Krawczak;D.N. Cooper and M. Krawczak

Opis

This work presents current knowledge of the molecular genetics of the protein factors relevant to venous thrombotic disease, and describes the molecular basis of the various known deficiency states. It brings together all the relevant information required for the identification, study and analysis of the underlying gene/protein defects. It covers protein structure, function and biochemistry, gene structure and expression, as well as epidemiological and molecular aspects of the deficiency state. Molecular models of the proteins and their dysfunctional variants are presented wherever possible.

Thrombotic disease is a major cause of death and disablement in Western society. Venous Thrombosis: from genes to clinical medicine presents our current knowledge of potentially prothrombotic protein abnormalities, together with clear and concise views of

Spis treści

Introduction; Pathological mutations: DNA sequence and protein structure; Evolution of the vitamin K-dependent coagulation factors; Antithrombin III and antithrombin III deficiency; Protein C and protein C deficiency; Protein S and protein S deficiency;

O autorze

D.N. Cooper; M. Krawczak