Biological Approaches to Spinal Disc Repair and Regeneration for Clinicians

ISBN-13: 9781626232501 / Angielski / Twarda / 2017 / 216 str.

Roger Hartl; Larry Bonassar

Spis treści

Part I: Basics
1. The Human Spinal Disc: Relevant Anatomy and Physiology
2. Pathophysiology of Disc Disease: Disc Degeneration
3. Imaging of the Healthy and Diseased Spinal Disc
4. Biomechanics of the Healthy and Diseased Spine
Part II: Experimental Techniques
5. Differences between Human and Animal Discs: Pros and Cons of Current Animal Models for Preclinical Development of Biological Therapies for Low Back Pain
6. Grading Scales for Disc Degeneration and Regeneration: Clinical and Experimental
7. Disc Regeneration: In Vitro Approaches and Experimental Results
8. Intervertebral Disc Whole Organ Cultures
Part III: Treatment Strategies
9. Biological Treatment Approaches: Basic Ideas and Principles
10. Learning from Successes of Tissue Engineering Strategies for Cartilaginous Disorders
11. Treatment of Degenerative Disc Disease and Disc Regeneration: Proteins and Genes
12. Treatment of Degenerative Disc Disease/Disc Regeneration: Growth Factors and Platelet Rich Plasma
13. Treatment of Degenerative Disc Disease/Disc Regeneration: Stem Cells, Chondrocytes or Other Cells, and Tissue Engineering
14. Nucleus Replacement and Repair: Autologous Disc Chondrocyte Transplantation
15. Annulus Fibrosus Repair
Part IV: Clinical Experience
16. Summary of Clinical Trials with Biological Treatment Approaches for Spinal Disease
17. Total Disc Transplantation: Current Results and Future Development
18. What HaveWe Learned from Mechanical Total Disc Replacement?
19. Regulatory Overview: Obtaining Regulatory Approval of a Biological/Cell Product
20. What Makes Biological Treatment Strategies and Tissue Engineering for DDD Interesting to Industry?
Part V: Outlook
21. What Will the Future Bring? Perspectives From Around the World