The Handbook of Metabolomics

ISBN-13: 9781617796173 / Angielski / Twarda / 2012 / 484 str.

Teresa Whei Fan; Andrew N. Lane; Richard M. Higashi

Opis

Vital to academic researchers, the medical field, and especially to biotech and pharmaceutical scientists, metabolomics is a rapidly expanding field that will provide a key link between functional biology (phenotypes) and the inner workings of cells in tissues or whole organisms. In The Handbook of Metabolomics, expert researchers provide readers with the current state of metabolomic development and the integration of metabolomics with transcriptomics and proteomics, illustrated by research efforts related to toxicology and pharmacology. The detailed contributions deal with topics ranging from sample preparation and considerations, both laboratory and clinical, analytical methodologies for metabolite and isotopomer profiling, metabolic flux modeling, database construction, and the integration of omics for systems biochemical understanding, amongst other topics. Thorough and authoritative, The Handbook of Metabolomics serves as an ideal reference for all those who wish to further pursue this promising area of study.

Spis treści

1. Introduction to Metabolomics

            Teresa Whei-Mei Fan, Andrew N. Lane, and Richard M. Higashi

 

2. Considerations of Sample Preparation for Metabolomics Investigation

            Teresa Whei-Mei Fan

 

3. Clinical Aspects of Metabolomics

            Michael Bousamra II, Jamie Day, Teresa Whei-Mei Fan, Goetz Kloecker, Andrew N. Lane, and Donald M. Miller

 

4. Structural Mass Spectrometry for Metabolomics

            Richard M. Higashi

 

5. Metabolomic Applications of Inductively Coupled Plasma- Mass Spectrometry (ICP-MS)

            Rob Henry and Teresa Cassel

 

6. Principles of NMR for Applications in Metabolomics

            Andrew N. Lane

 

7. Novel NMR and MS Approaches to Metabolomics

            Ian A. Lewis, Michael R. Shortreed, Adrian D. Hegeman, and John L. Markley

 

8. Metabolic Flux Analysis

            Tae Hoon Yang

 

9. Introduction to Metabolic Control Analysis (MCA)

            Joy Maliackal Poulo, Timothy C. Elston, Andrew N. Lane, Jeffrey M. Macdonald, and Marta Cascante

 

10. Application of Tracer-Based Metabolomics and Flux Analysis in Targeted Cancer Drug Design

            Marta Cascante, Vitaly Selivanov, and Antonio Ramos-Montoya

 

11. Non-Invasive Fluxomics in Mammals by Nuclear Magnetic Resonance Spectroscopy

            Justyna Wolak, Kayvan Rahimi-Keshari, Rex E. Jeffries, Maliackal Poulo Joy, Abigail Todd, Peter Pediatitakis, Brian Dewar, Jason H. Winnike, Oleg Favorov, Timothy Elston, Lee M. Graves, John Kurhanewicz, Daniel Vigneron, Ekhson Holmuhamedov, and Jeffrey M. Macdonald

 

12. Compositional Analysis of Phospholipids by Mass Spectrometry and Phosphorus-31 Nuclear Magnetic Resonance Spectroscopy

            M. Cecilia Yappert

 

13. The HumanCyc Pathway-Genome Database and Pathway Tools Software as Tools for Imaging and Analyzing Metabolomics Data

            Pedro Romero

 

14. Metabolomics-Edited Transcriptomics Analysis (META)

            Teresa Whei-Mei Fan