In Vivo Neuromethods

ISBN-13: 9781617370564 / Angielski / Miękka / 2010 / 396 str.

Alan A. Boulton; Glen B. Baker; Alan N. Bateson

Opis

A superb collection of time-tested, key techniques for investigating nervous system function, as well as the actions of drugs on the nervous system. The methods range from authoritative treatment of such well-established techniques as recording electrical activity in the brain, to practical coverage of state-of-the-art methods, including neural transplantation and antisense technology. The techniques described are particularly suitable for studying the mechanisms of action of psychotropic drugs and drugs of abuse, as well as the etiology and pharmacotherapy of neuropsychiatric diseases and neurodegenerative disorders. Several of the methods detailed are highly useful in screening potential drugs for the treatment of depression, anxiety disorders, schizophrenia, and Parkinson's and Alzheimer's disease.

Spis treści

In Vivo Brain Microdialysis: Principles and Applications, A. Adell and F. Artigas. In Vivo Methods for Studying Receptors, R. S. Neuman. Neural Transplantation, S. B. Dunnett. Animal Models of Anxiety and Depression, D. Treit and J. Menard. Animal Models of Neurological Disorders, K. G. Todd and R. F. Butterworth. Preclinical Behavioral Approaches to the Identification and Study of Antipsychotic Drug Action and Schizophrenia, S. A. Josselyn and F. J. Vaccarino. Preclinical Behavioral Approaches for Assessing the Reinforcing Properties of Drugs of Abuse, N. J. DeSousa and F. J. Vaccarino. In Vivo Animal Models of Tetratogenicity, A. J. Nazarali and R. Puthucode. Antisense Oligodeoxynucleotide Technology: Application to CNS Neuropharmacology, A.-M. Ouagazzal, J. M. Tepper, and I. Creese. The Relation of Brain Electrical Activity to Behavior, C. H. Vanderwolf and L.-W. S. Leung. Electrical and Chemical Stimulation of Brain Tissue In Vivo, A. J. Greenshaw. Index.

Blurb

In Vivo Neuromethods is the first of three successor works that update and expand the best-selling inaugural volume of Humana Press's warmly-received Neuromethods series, General Neurochemical Techniques (vol. 1). This important new book offers critical reviews of key techniques for investigating nervous system function, as well as the actions of drugs on the nervous system. The surveys range from authoritative treatment of such well-established techniques as the recording of electrical activity in the brain, to practical coverage of state-of-the-art methods, including neural transplantation and antisense technology. The techniques described are particularly suitable for studying the mechanisms of action of psychotropic drugs and drugs of abuse, as well as the etiology and pharmacotherapy of neuropsychiatric diseases and neurodegenerative disorders. Several of the methods detailed are highly useful in screening potential drugs for the treatment of depression, anxiety disorders, schizophrenia, and Parkinson's and Alzheimer's disease.

The companion volumes, Molecular Neurobiology Techniques and Cell Neurobiology Techniques concentrate on in vitro approaches. Like their original predecessor, all three cutting-edge works will prove exceptionally useful to those basic and clinical neuroscientists who want to expand the range of their current research, or to develop competence in complimentary methods.