Pharmacokinetics for the Pharmaceutical Scientist

ISBN-13: 9781566760324 / Angielski / Twarda / 1993 / 336 str.

John G. Wagner; Wagner G. Wagner

Opis

Major presentation of pharmacokinetics by a leading international expert. Methods for: estimating drug disposition parameters from data obtained after intravascular or extravascular drug administration, estimating rate and extent of drug bioavailability, and comparing rate and extent of drug availability following administration of several different dosage forms of a drug.

Recenzje

"This is a very complete book on modeling the pharmacokinetics of drugs. . . It is one of the very few advanced texts in the field, written by one of the founders of the field and is written with a distilled insight that can only be obtained from years of experience in the field. I highly recommend it."
--Elke Lipka for Pharmaceutical News

Spis treści

Simple Linear Models

More Complicated Linear Models

Complicated Linear Models

Linear Multicompartment Disposition Parameters from Extravascular Downslope
C,T Data

Noncompartmental and System Analysis Linear Multiple Dose Equations

Simple Nonlinear Models

More Complicated Nonlinear Models

Urinary Excretion

Absorption Analysis and Bioavailability

Physiological Pharmacokinetics

Relationship between Physiologically Based Flow Models and Usual Compartment
Models

Protein Binding

Pharmacokinetic

Pharmacodynamic Modelling

Metabolic Kinetics

Laplace Derivation of Linear Pharmacokinetic Equations

Measures of Fit

Appendix

Index


175 Figures and Schematics, 51 Tables, 134 References

O autorze

Wagner, John G.