Neutron Beam Design, Development, and Performance for Neutron Capture Therapy

ISBN-13: 9781468458046 / Angielski / Miękka / 2012 / 364 str.

Otto K. Harling; John A. Bernard;Robert C. Zamenhof

Opis

For this Workshop, the organizers have attempted to invite experts from all known centers which are engaged in neutron beam development for neutron capture therapy. The Workshop was designed around a series of nineteen invited papers which dealt with neutron source design and development and beam characterization and performance. Emphasis was placed on epithermal beams because they offer clinical advantages and are more challenging to implement than thermal beams. Fission reactor sources were the basis for the majority of the papers; however three papers dealt with accelerator neutron sources. An additional three invited papers provided a summary of clinical results of Ncr therapy in Japan between 1968 and 1989 and overviews of clinical considerations for neutron capture therapy and of the status of tumor targeting chemical agents for Ncr. Five contributed poster papers dealing with NCT beam design and performance were also presented. A rapporteurs' paper was prepared after the Workshop to attempt to summarize the major aspects, issues, and conclusions which resulted from this Workshop. Many people contributed to both the smooth functioning of the Workshop and to the preparation of these proceedings. Special thanks are reserved for Ms. Dorothy K.

Spis treści

Rapporteurs’ Report.- Rapporteurs’ Report.- Overviews of Clinical Experience, Clinical Considerations, and Tumor Targeting.- Clinical Results of Boron Neutron Capture Therapy.- Clinical Considerations for Neutron Capture Therapy of Brain Tumors.- Tumor Targeting Agents for Neutron Capture Therapy.- Neutron Beam Design.- Monte Carlo Methods of Neutron Beam Design for Neutron Capture Therapy at the MIT Research Reactor (MITR-II).- Neutron Capture Therapy Beam Design at Harwell.- Physics Design for the Brookhaven Medical Research Reactor Epithermal Neutron Source.- A Calculational Study of Tangential and Radial Beams in HIFAR for Neutron Capture Therapy.- Research on Neutron Beam Design for BNCT at the Musashi Reactor.- Neutron Beam Studies for a Medical Therapy Reactor.- Investigation of Neutron Beams for the Realization of Boron Neutron Capture Therapy.- Intermediate Energy Neutron Beams from the MURR.- Reactor-Based Neutron Beams.- Progress Towards Boron Neutron Capture Therapy at the High Flux Reactor Petten.- Installation and Testing of an Optimized Epithermal Neutron Beam at the Brookhaven Medical Research Reactor (BMRR).- Neutron Capture Therapy Beams at the MIT Research Reactor.- Georgia Tech Research Reactor Epithermal Beam.- Neutron Beam Design and Performance for BNCT in Czechoslovakia.- Neutron Spectrum Measurements in the Aluminum Oxide Filtered Beam Facility at the Brookhaven Medical Research Reactor.- Accelerator-Based Neutron Beams.- The Possible Use of a Spallation Neutron Source for Neutron Capture Therapy with Epithermal Neutrons.- A Versatile, New Accelerator Design for Boron Neutron Capture Therapy: Accelerator Design and Neutron Energy Considerations.- An Experimental Study of the Moderator Assembly for a Low-Energy Proton Accelerator Neutron Irradiation Facility for BNCT.- Dosimetry and Treatment Planning.- Monte Carlo Based Dosimetry and Treatment Planning for Neutron Capture Therapy of Brain Tumors.- Epithermal Beam Development at the BMRR: Dosimetric Evaluation.- A Beam-Modification Assembly for Experimental Neutron Capture Therapy of Brain Tumors.- Biomedical Irradiation System for Boron Neutron Capture Therapy at the Kyoto University Reactor.- Session Chairmen.- Participants.