This concise book reviews the current science of mucosal immune responses to infectious agents. The seven chapters share details of the immune responses found in various types of mucosal surfaces from the anogenital, gastrointestinal oral, pulmonary, and ophthalmic. The high quality figures and pictures are aid in the understanding of the clinical presentation of infections at the mucosal level.

The primary focus of this book is to review the new discoveries that lead to the understanding of how immunity at the mucosal level protects the host. The field of immunology in general has grown tremendously in the last decade. This information will lead to new protective vaccines that will be based on a basic understanding of immune function. This book details some new vaccines that are designed to stimulate mucosal immunity.

Professional scientists studying immune function or infectious diseases are the intended audience. The authors have compiled their expertise in this area to put together a well organized review of mucosal immunity.

This book covers the immune response elicited from each of the various mucosal surfaces in humans. An interesting quote from the book in chapter 2 states, "Mucous membranes comprise.a surface area of about the size of one and a half tennis courts, about 200 times the area of the skin." This comment put the study of immunity at the mucosal membrane level in perspective. Many pathogenic organisms cause infection after encountering the mucosal surface. Both the innate and adaptive host defenses in these tissues become a high priority when viewed in that context. The information in this book will enhance the development of vaccines that are more protective and that are delivered to the site at the highest risk for invasion with an infectious agent.

This well written textbook has some unique perspectives on immune responses. Often we have focused the study of immune response on the systemic immune system. This book shows the importance of the local mucosal immunity. I would recommend this book to any professional who studies immunity or infectious diseases.

Rebecca Horvat, PhD, D(ABMM)(University of Kansas Medical Center)

The Role of Mucosal Immunity in Protection against Viral Diseases.- Anogenital Mucosal Immunology and Virology.- Gastrointestinal Mucosal Immunology.- Virology of the Gastrointestinal Tract.- Oral Manifestations of Viral Diseases.- Common Respiratory Viruses and Pulmonary Mucosal Immunology.- Ophthalmic Manifestations of Viral Diseases.

Professor Tyring is the Medical Director of the UTMB Center for Clinical Studies in Houston, TX and is a highly experienced dermatologist, being a reviewer for the Journal of the American Academy of Dermatology and a member of the American Academy of Dermatology Committee on Sexually Transmitted Diseases. He is also a member of the Sealy Center for Vaccine Development (University of Texas Medical Branch), the Society for Experimental Biology and Medicine and a Fellow of the Infectious Disease Society of America. He has also edited a number of books including Mucocutaneous Manifestations of Viral Diseases published by Marcel Dekker and Human Papillomaviruses published by OUP.

An understanding of viral infection and the underlying role of the immune system in protection against these diseases is vital in today’s medical climate. Previously, only symptoms could be treated, as no antiviral therapies existed in clinical medicine. The increasing amounts of research and discoveries of immunologic agents and pathways have enabled specialists to observe the basic physiology of the various disease processes as never before and provide effective management options tailor-made for patients. Mucosal Immunology and Virology is designed to provide the clinician with a thorough and yet approachable textbook describing the relationships between immunology, virology and the disease process. It includes a vast wealth of information and illustrations to enable the reader to become familiar with the clinical presentation of these diseases, the tests needed to establish the diagnosis, and the treatment of the disease including specific antiviral agents. Suitable for residents and clinicians in immunology, infectious diseases, internal medicine and dermatology the book reviews the systematic manifestations of mucosal viral infections, including those involving the mouth, gastrointestinal tract, respiratory system, anogenital mucosa and ocular infections

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