Innate Immune Regulation and Cancer Immunotherapy

ISBN-13: 9781441999139 / Angielski / Twarda / 2011 / 478 str.

Rongfu Wang

Opis

Innate and adaptive immunity play important roles in immunosurveillance and tumor destruction. However, increasing evidence suggests that tumor-infiltrating immune cells may have a dual function: inhibiting or promoting tumor growth and progression. Although regulatory T (Treg) cells induce immune tolerance by suppressing host immune responses against self- or non self-antigens, thus playing critical roles in preventing autoimmune diseases, they might inhibit antitumor immunity and promote tumor growth. Recent studies demonstrate that elevated proportions of Treg cells are present in various types of cancers and suppress antitumor immunity. Furthermore, tumor-specific Treg cells can inhibit immune responses only when they are exposed to antigens presented by tumor cells. Therefore, Treg cells at tumor sites have detrimental effects on immunotherapy directed to cancer.

Spis treści

Introduction.- The role of NKT cells in the immune regulation of neoplastic disease.- γδ T Cells in Cancer.- Toll-like receptors and their regulatory mechanisms.- Cytoplasmic sensing of viral double-stranded RNA and activation of innate immunity by RIG-I-Like Receptors.- Innate immune signaling and negative regulators in cancer.- Dendritic Cell Subsets and Immune Regulation.- Human Dendritic Cells in Cancer.- Regulatory T cells in cancer.- Relationship between Th17 and regulatory T cells in the tumor environment.- Mechanisms and control of regulatory T cells in cancer.- Myeloid Derived Suppressor Cells in Cancer.- Myeloid Derived Suppressor Cells and Treg cells in Tumor Microenvironment.- Cell Surface Co-Signaling Molecules in the Control of Innate and Adaptive Cancer Immunity.- Negative regulators of NF-κB activation and type I interferon pathways.- Role of TGF-β in immune suppression and inflammation.- Indoleamine 2,3-dioxygenase and tumor-induced immune suppression.- Myeloid-Derived Suppressor Cells in Cancer:  Mechanisms and Therapeutic Perspectives.- Human tumor antigens recognized by T cells and their implications for cancer immunotherapy.- Cancer/testis (CT) Antigens: Potential Targets for Immunotherapy.- Tumor antigens and Immune Regulation in Cancer Immunotherapy.- Immunotherapy of Cancer.- Current Progress in Adoptive T-Cell Therapy of Lymphoma.- Adoptive Immunotherapy of Melanoma.- Index.

Blurb

There has been major growth in understanding innate immune signaling, inflammation, immune suppression and cancer immunotherapy. Innate immune regulation and cancer immunotherapy highlights emerging research about the underlying mechanisms of innate immunity and signaling regulation, inflammation and immune suppression that promote or inhibit cancer development and progression, and offers novel ideas and strategies to develop therapeutic cancer drugs or cell therapy by manipulating or blocking these negative signaling pathways and generating potent antitumor immunity.  Recent studies have identified key innate immune receptors or sensors, novel signaling molecules and immune regulatory molecules that control immune responses, inflammation and immune suppression in cancer and other diseases. Major progresses in understanding of tumor antigens, immune suppressive molecules and cell population and novel vaccine strategies bring therapeutic cancer vaccines and drugs in realty.  With chapters written by internationally recognized contributors, this book provides essential introduction and guide for immunologists, basic, translational and clinical cancer researchers.

Features of this book:

Offers the most recent development from basic science to clinical application of cancer immunotherapy, thus serving useful guide for immunologists, and cancer researcher and oncologists.

Identify key immune signaling molecules and cell populations that dampen immune responses against cancer, thus providing novel strategies to develop therapeutic cancer vaccines and drugs.