Chromatin and Disease

ISBN-13: 9781402054655 / Angielski / Twarda / 2007 / 458 str.

Tapas K. Kundu; Dipak Dasgupta

Opis

This book includes a collection of articles with the broad theme of disease connection to chromatin structure and function. It elaborates on the molecular pharmacology of the drugs targeting chromatin structure and its components. The book contains up-to-date information about the chromatin structure and chromatin related diseases and drug functions. This work is the first endeavor to present different aspects encompassing the above theme.

Spis treści

PART I: Chromatin Structure, Dynamics and Disease 1 Structural organization of dynamic chromatin in humans. Kohji Hizume, Shige H. Yoshimura and Kunio Takeyasu 2 Chromatin Remodeling: Action and Reaction. Parul Choudhary and Patrick Varga-Weisz 3 Regulation of Chromatin Structure and Transcription by Poly (ADP- Ribose) Polymerase- I: Possible targets for drug based therapies. David A. Wacker, Kristine M. Frizzell, and W. Lee Kraus 4 Histone variant nucleosomes: structure, function and implication in disease. Mathieu Boulard, Philippe Bouvet, Tapas K Kundu and Stefan Dimitrov 5 Histone variants and complexes involved in their exchange. Thomas Kusch and Jerry L. Workman 6 Histone chaperones in chromatin dynamics: Implication in disease manifestation. Jayasha Shandilya, Shrikanth Gadad, V.Swaminathan and Tapas K. Kundu 7 Function of the histone chaperone Nucleolin in diseases. Sébastien Storck, Manu Shukla, Philippe Bouvet 8 Chromatin as a target for the DNA binding anti-cancer drugs. Parijat Majumder, Suman K. Pradhan, Pukhrambam Grihanjali Devi, Sudipta Pal and Dipak Dasgupta PART II: Nonhistone Proteins, Sites for Epigenetic Marks: link to Disease. 9 Reversible acetylation of Non Histone proteins: Role in cellular function and disease. Kiran Batta, Chandrima Das, Shrikanth Gadad, Jayasha Shandilya and Tapas K. Kundu 10 MARs and MARBPs: Key modulators of gene regulation and disease manifestation. Samit Chattopadhyay and Lakshminarasimhan Pavithra PART III : Epigenetic Modifications of Chromatin : Implication in Disease and Therapeutics. 11 Aberrant forms of acetyltransferases in human diseases. Olivier van Beekum and Eric Kalkhoven 12 Chromatin acetylation status in the manifestation of neurodegenerative diseases: HDAC inhibitors as therapeutic tools? Anne-Laurence Boutillier, CarolineRouaux, Panteleeva 13 Function of MYST family Histone acetyltransferases and their link to diseases. Nikita Avvakumov and Jacques Cote 14 Role of histone phosphorylation in chromatin dynamics and its implication in diseases. Masaya Oki, Hitoshi Aihara and Takashi Ito 15 Function of euchromatic histone H3K9 methyltransferases, G9a/GLP. Yoichi Shinkai 16 Histone acetylation and methylation: Combinatorial players for transcriptional regulation Woojin An 17.Chromatin modifying enzymes and HIV gene expression. Vincent Quivy, Stéphane de Walque, and Carine Van Lint 18.Small Molecule Modulators in Epigenetics: Implication in gene expression and therapeutics. V.Swaminathan, B.A.Ashok Reddy, Selvi R, Sukanya.M.S. and Tapas K. Kundu Index