Genetics of Asthma and Chronic Obstructive Pulmonary Disease

ISBN-13: 9780849369667 / Angielski / Twarda / 2006 / 414 str.

Dirkje S. Postma; Scott T. Weiss

Opis

Exploring new pathways for the development of pharmacological agents and methods for disease intervention, this source includes chapters on genetic epidemiology, techniques in statistical analysis, and the use of animal models for the study of airway disease genetics presents the results of recent linkage and association studies and epigenetic and environmental influences, and considers their impact on the future management of asthma and COPD considers the development of proteomic strategies to possibly detect relevant proteins in disease development and progression weighs the possibility that both asthma and COPD have common genetic origins and may represent different expressions of a similar disease process Responding to the substantial growth that has taken place in the field over the past decade, this reference provides an in-depth overview of current thought on the genetics and genomics of asthma and COPD in relation to their pathogenesis and treatment. With contributions by an esteemed team of international authorities on the topic, this source spans the latest developments in the utilization of microarray techniques, linkage and association studies, mapping strategies, comparative genetics, microarray techniques, proteomics, and pharmacogenomics.

Spis treści

"Introduction to Genetics. Genetic Epidemiology of Reduced Lung Function.
Gene-Environment Interaction in Asthma. Epistatic Interaction, Age and Gender Effects.
Microarray Techniques and Data in Asthma/COPD. Mouse Models for Asthma and Mouse Asthma Genetics. Knock out Models for Asthma. Comparative Genomics of Asthma.
Proteomic Techniques for Asthma and COPD Research. Linkage to Asthma and Its Intermediate Phenotypes. Linkage Analysis of Spirometric Phenotypes and COP. Fine Mapping and Whole Genome Association Studies in Asthma and COPD. Association Studies in Asthma. Association Studies in COPD. b-Adrenergic Receptor. IL13. CD14 and Toll-like Receptors. Pharmacogenetics

O autorze

Dirkje S. Postma, Scott T. Weiss