Percutaneous Penetration Enhancers

ISBN-13: 9780849321528 / Angielski / Twarda / 2005 / 448 str.

Eric W. Smith; Howard I. Maibach

Opis

Thoroughly updated, this second edition is the most comprehensive reference on the methods available for the enhancement of percutaneous penetration. The book examines a broad scope of chemical enhancers and various physical methods of enhancement. The range of chemicals discussed is, arguably, unsurpassed anywhere in the literature. This edition contains comprehensive descriptions of the latest techniques and several chapters cover the modern analytical techniques adapted to assess and measure penetration enhancement. New to this volume are chapters addressing penetration retardation, important for substances such as sunscreen agents, for which skin penetration is not desirable.

Spis treści

INTRODUCTION Penetration Enhancer Classification, B.W. Barry Structure–Activity Relationship of Chemical Penetration Enhancers, N. Kanikkannan, J.B. Ramapuram, and M. Singh Quantitative Structure–Enhancement Relationship and the Microenvironment of the Enhancer Site of Action, S.K. Li and W.I. Higuchi The Role of Prodrugs in Penetration Enhancement, K.B. Sloan and S.C. Wasdo VEHICLE EFFECTS IN PENETRATION ENHANCEMENT Penetration Enhancement by Skin Hydration, J. Zhang, C.H. Purdon, E.W. Smith, H.I. Maibach, and C. Surber Enhancement of Delivery with Transdermal Sprays, B.C. Finnin and J. Hadgraft Hydrogel Vehicles for Hydrophilic Compounds, T. Cerchiara and B. Luppi Enhanced Skin Permeation Using Ethosomes, E. Touitou and B. Godin Microemulsions in Topical Drug Delivery, S. Pappinen and A. Urtti Nanoparticles as Carriers for Enhanced Skin Penetration, S. Miyazaki Solid Lipid Nanoparticles for Topical Delivery, Z. Mei Fatty Alcohols and Fatty Acids, R.J. Babu, M. Singh, and N. Kanikkannan Essential Oils and Terpenes, R.A. Thakur, Y. Wang, and B.B. Michniak PHYSICAL METHODS OF PENETRATION ENHANCEMENT Iontophoresis: Clinical Applications and Future Challenges, N. Abla, A. Naik, R.H. Guy, and Y.N. Kalia Electroporation, B.M. Medi and J. Singh Micron, M.R. Prausnitz, J.A. Mikszta, and J. Raeder-Devens Vesicles under Voltage, M.C. Bonner and B.W. Barry ASSESSMENT OF PENETRATION ENHANCEMENT Mechanistic Studies of Permeation Enhancers, S.K. Li and W.I. Higuchi Penetration Enhancer Assessment by Corneoxenometry, C. Pie´rard-Franchimont, F. Henry, E. Uhoda, C. Flagothier, and G.E. Pie´rard Assessment of Vehicle Effects by Skin Stripping, C.H. Purdon, C. Pellanda, C. Surber, and E.W. Smith The Use of Skin Alternatives for Testing Percutaneous Penetration, C.S. Asbill, G.W. Bumgarner, and B.B. Michniak High Throughput Screening of Transdermal Penetration Enhancers: Opportunities, Methods, and Applications, A. Jain, P. Karande, and S. Mitragotri Confocal Laser Scanning Microscopy: An Excellent Tool for Tracking Compounds in the Skin, D.D. Verma and A. Fahr THE RETARDATION OF PERCUTANEOUS PENETRATION Fundamentals of Retarding Penetration, J. Hadgraft and B.C Finnin Retardation Strategies for Sunscreen Agents, C.H. Purdon, E.W. Smith, and C. Surber Military Perspectives in Chemical Penetration Retardation, E.H. Braue, Jr., B.F. Doxzon, H.L. Lumpkin, K.A. Hanssen, R.S. Stevenson, R.R. Deckert, and J.S. Graham COMMERCIAL APPLICATIONS OF PENETRATION ENHANCERS Preclinical and Clinical Development of a Penetration Enhancer SEPA 0009, T.C. K. Chan Index

O autorze

Eric Wane Smith, Howard I. Maibach