Peptide Antibiotics: Discovery Modes of Action and Applications

ISBN-13: 9780824702458 / Angielski / Twarda / 2001 / 308 str.

Christopher J. Dutton; Mark A. Haxell; Hamish A. I. McArthur

Opis

This reference summarizes the latest research on the structure, function, and design of synthetic and natural peptide antibiotics, describing practical applications of these compounds in food preservation and packaging, and in the prevention and treatment of infectious diseases by direct anti-bacterial action and as part of the adaptive immune response.
Peptide Antibiotics discusses these unique compounds and their many and exciting applications, including:

the distribution and classification of diverse antimicrobial peptides throughout nature

the role in host defense of mucosal surface peptide antibiotics such as defensins and cathepsins

the biosynthesis of lanthionine-containing antibiotics including nisin, epidermin, and mersacidin

the genetic basis determining the production of bacterial peptide antibiotics

the potential commercial use of magainin, nisin, and lacticin peptides as anti-infective agents

the use of nisin as a commercial food preservative
With contributions from 19 world-renowned experts in the field, Peptide Antibiotics is an indispensable source of information for pharmaceutical scientists, medicinal and organic chemists and biochemists, microbiologists, infectious disease specialists, molecular biologists, and upper-level undergraduate and graduate students in these disciplines.

Spis treści

Introduction to the Peptide Antibiotics
Harry W. Taber

Sources of Antimicrobial Peptides

Chemistry and Applications of Synthetic Antimicrobial Peptides
David Andreu and Luis Rivas

Lanthionine-Containing Bacterial Peptides
Ulrike Pag and Hans-Georg Sahl

Unmodified Peptide-Bacteriocins (Class II) Produced by Lactic Acid Bacteria
Ingolf F. Nes, Helge Holo, Gunnar Fimland, Håvard Hildeng Hauge, and Jon Nissen-Meyer

Insect Cationic Antimicrobial Peptides
Charles Hetru, Jules A. Hoffmann, and Robert E. W. Hancock

Mammalian Antimicrobial Peptides
Charles L. Bevins and Gill Diamond

Potential Applications of Peptides

Exploitation of Lantibiotic Peptides for Food and Medical Uses
Máire P. Ryan, Colin Hill, and R. Paul Ross

Amphibian Antimicrobial Peptides
Michael A. Zasloff

Index

O autorze

Christopher J. Dutton is Senior Principal Scientist, Pfizer Global Research and Development, Sandwich, Kent, England. He is a Fellow of the Royal Society of Chemistry and a member of the Society for Medicines Research. Dr. Dutton received the Ph.D. degree (1983) from Cambridge University, England. Mark A. Haxell is Licensing Coordinator, Pfizer Global Research and Development, Sandwich, Kent, England. A member of the Licensing Executives Society, he received the Ph.D. degree (1983) in microbiology from Liverpool John Moores University, Liverpool, England. Hamish A. I. McArthur is Assistant Director, Bioprocess Research and Development, Pfizer Global Research, Groton, Connecticut. A member of the Society for General Microbiology and the American Society for Microbiology, Dr. McArthur received the Ph.D. degree (1975) in microbial biochemistry from St. John's College, University of Cambridge, England. Richard G. Wax is Principal Research Investigator, Pfizer Global Research, Groton, Connecticut. He is a member of the American Society for Microbiology and the Society for Industrial Microbiology. Dr. Wax received the Ph.D. degree (1963) in biophysics from the Pennsylvania State University, University Park.