Systems Biology: Properties of Reconstructed Networks

ISBN-13: 9780521859035 / Angielski / Twarda / 2006 / 336 str.

Bernhard O. Palsson

Opis

Genome sequences are now available that enable us to determine the biological components that make up a cell or an organism. The new discipline of systems biology examines how these components interact and form networks, and how the networks generate whole cell functions corresponding to observable phenotypes. This textbook describes how to model networks, determine their properties, and relate these to phenotypic functions. Some knowledge of linear algebra and biochemistry is required, since the book reflects the irreversible trend of increasing mathematical content in biology education.

Recenzje

'… [deserves] serious attention from any quantitative scientist or physicist who hopes to learn about modern biology … a welcome departure from the typical biology textbook … a very readable introduction to the subject … this is an exciting time for biology. The author exposes readers to enough material that the research literature in quantitative systems biology should become accessible.' Physics Today

Spis treści

Preface; 1. Introduction; 2. Basic concepts in systems biology; Part I. Reconstruction of Biochemical Networks: 3. Metabolic networks; 4. Regulatory networks; 5. Signalling networks; Part II. Mathematical Representation of Reconstructed Networks: 6. Basic features of S; 7. Topological properties; 8. Fundamental subspaces; 9. Null space of S; 10. The left null space of S; 11. The row and column spaces of S; Part III. Capabilities of Reconstructed Networks: 12. Dual causality; 13. Properties of solution spaces; 14. Sampling properties of solution spaces; 15. Finding functional states; 16. Parametric sensitivity; 17. Epilogue; Appendix A: nomenclature and abbreviations; Appendix B: E. coli core metabolic network; Bibliography; Index.