Biodegradable Polymers in Clinical Use and Clinical Development

ISBN-13: 9780470424759 / Angielski / Twarda / 2011 / 752 str.

Abraham J. Domb; Neeraj Kumar

Opis

This book focuses on biodegradable polymers that are already in clinical use or under clinical development. Synthetic and natural polymers will be included. This excludes polymers that have been investigated and did not reach clinical development.

The purpose of this book is to provide updated status of the polymers that are clinical use and those that are now being developed for clinical use and hopefully will reach the clinic during the next 5 years. The book provides information that of interest to academics and practicing researchers including chemists, biologists and bioengineers and users: physicians, pharmacists.

Spis treści

CONTRIBUTORS.

PREFACE.

PART I GENERAL.

1 Biodegradable Polymers in Drug Delivery (Jay Prakash Jain, Wubante Yenet, Abraham J. Domb, and Neeraj Kumar).

PART II BIODEGRADABLE POLYMERS OF NATURAL ORIGIN: PROTEIN–BASED POLYMERS.

2 Collagen (Wahid Khan, Deepak Yadav, Abraham J. Domb, and Neeraj Kumar).

3 Properties and Hemostatic Application of Gelatin (Jalindar Totre, Diana Ickowicz, and Abraham J. Domb).

PART III BIODEGRADABLE POLYMERS OF NATURAL ORIGIN: POLYSACCHARIDES.

4 Chitosan and Its Derivatives in Clinical Use and Applications (Anuradha Subramanian, Kirthanashri Srinivasan Vasanthan, Uma Maheswari Krishnan, and Swaminathan Sethuraman).

5 Clinical Uses of Alginate (Udi Nussinovitch and Amos Nussinovitch).

6 Dextran and Pentosan Sulfate Clinical Applications (Ramu Parthasarathi and Athipettah Jayakrishnan).

7 Arabinogalactan in Clinical Use (Rajendra P. Pawar, Babasaheb A. Kushekar, Bhaskar S. Jadhav, Kiran R. Kharat, Ravikumar M. Borade, and Abraham J. Domb).

PART IV BIODEGRADABLE POLYMERS OF NATURAL ORIGIN: POLYESTERS.

8 Polyhydroxyalkanoate (Kesaven Bhubalan, Wing–Hin Lee, and Kumar Sudesh).

PART V SYNTHETIC BIODEGRADABLE POLYMERS.

9 Lactide and Glycolide Polymers (Kevin Letchford, Anders Sodergard, David Plackett, Samuel Gilchrist, and Helen Burt).

10 Polyanhydrides Poly(CPP–SA), Fatty–Acid–Based Polyanhydrides (Ravikumar M. Borade, Abraham J. Domb, Archana A. Sawale, Rajendra P. Pawar, and Kiran R. Kharat).

11 Poly(e–Caprolactone–co–Glycolide): Biomedical Applications of a Unique Elastomer (Kevin Cooper, Aruna Nathan, and Murty Vyakarnam).

12 Medicinal Applications of Cyanoacrylate (Rajendra P. Pawar, Ashok E. Jadhav, Sumangala B. Tathe, Bhimrao C. Khade, and Abraham J. Domb).

13 Polyethylene Glycol in Clinical Application and PEGylated Drugs (Teerapol Srichana, and Tan Suwandecha).

PART VI INORGANIC POLYMERS.

14 Calcium–Phosphate–Based Ceramics for Biomedical Applications (Qing Lv, Kevin W.–H. Lo, Lakshmi S. Nair, and Cato T. Laurencin).

PART VII BIODEGRADABLE POLYMERS FOR EMERGING CLINICAL USES.

15 Biocompatible Polymers for Nucleic Acid Delivery (Jeff Sparks, and Khursheed Anwer).

16 Biodegradable Polymers for Emerging Clinical Use in Tissue Engineering (Shalini Verma, Kalpna Garkhal, Anupama Mittal, and Neeraj Kumar).

17 Injectable Polymers (Shimon A. Unterman, Norman A. Marcus, and Jennifer H. Elisseeff).

PART VIII IPR ASPECTS OF BIODEGRADABLE POLYMERS.

18 Global Patent and Technological Status of Biodegradable Polymers in Drug Delivery and Tissue Engineering (Parikshit Bansal, Shalini Verma, Wahid Khan, and Neeraj Kumar).

Index.

O autorze

ABRAHAM J. DOMB is Professor of Medicinal Chemistry and Natural Products at the School of Pharmacy, the Hebrew University. Following time at Syntex Research in California, and MIT/Harvard as a research associate, he founded and headed the Drug Delivery and Polymer division at Nova Pharmaceuticals in Baltimore. Dr. Domb′s primary research interests are in biopolymers, gene therapy, controlled drug delivery, cancer therapy, biodegradable polymers, hydrogels, coating of medical devices, nanoparticulate systems, and polymeric complexes.

NEERAJ KUMAR is Assistant Professor of Pharmaceutics at the National Institute of Pharmaceutical & Educational Research (NIPER), India. He obtained his PhD at the Indian Institute of Technology, Roorkee, India, before being appointed as Lady Davis Postdoctoral Fellow at the Hebrew University of Jerusalem. Dr. Kumar′s current interests are in biomaterials, tissue engineering, drug delivery, and hydrogels.

AVIVA EZRA is a researcher at the Institute of Drug Research, School of Pharmacy, The Hebrew University of Jerusalem. She earned her PhD in pharmaceutics from the School of Pharmacy. Dr. Ezra′s research interests include pharmaceutics, drug delivery systems, and pharmaceutical analysis.

Blurb

The definitive guide to biodegradable polymer science where we are and what′s to come

The most comprehensive review of biodegradable polymers already utilized or under development for clinical use, Biodegradable Polymers in Clinical Use and Clinical Development looks at the state of biodegradable polymers now and over the next five years.

Implantable molecules that break down within the body over a predetermined period of time, biodegradable polymers have been employed as drug carriers, orthopedic fixation devices, and absorbable sutures. Yet while hundreds of such polymers have been developed and tested in animals, only a few have been approved or evaluated for human use.

Made up of contributions from internationally renowned experts in polymer science from around the globe, this edited volume brings together coverage of:

• Natural biodegradable polymers (including polysaccharides and polyesters)

• Synthetic biodegradable polymers

• Inorganic polymers

• Biodegradable polymers for emerging clinical uses

An invaluable resource for research professionals in industry and academia, including those working in chemistry, biology, materials and biomaterials science, bioengineering/biomedical, and environmental studies, the book is also aimed at the medical practitioners and pharmacists who already use biodegradable polymers.